Global gene expression analysis reveals evidence for decreased lipid biosynthesis and increased innate immunity in uninvolved psoriatic skin.
Global gene expression analysis reveals evidence for decreased lipid biosynthesis and increased innate immunity in uninvolved psoriatic skin.
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整体基因表达分析揭示了未受累银屑病皮肤脂质生物合成减少和先天免疫力增加的证据。
DOI：
10.1038/jid.2009.173
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发表时间：
2009-12
影响因子：
6.5
通讯作者：
Elder, James T.
中科院分区：
文献类型：
--
作者：
Gudjonsson, Johann E.;Ding, Jun;Li, Xing;Nair, Rajan P.;Tejasvi, Trilokraj;Qin, Zhaohui S.;Ghosh, Debashis;Aphale, Abhishek;Gumucio, Deborah L.;Voorhees, John J.;Abecasis, Goncalo R.;Elder, James T.
Psoriasis is a genetically determined inflammatory skin disease. Although the transition from uninvolved into lesional skin is accompanied by changes in the expression of multiple genes, much less is known about the difference between uninvolved skin from psoriatic patients as opposed to skin from normal individuals. Multiple biochemical and morphological changes were reported decades ago in uninvolved psoriatic skin but remain poorly understood. Here we demonstrate dysregulation of 223 transcripts representing 179 unique genes in uninvolved psoriatic skin, 178 of which were not previously known to be altered in their expression. The proteins encoded by these transcripts are involved in lipid metabolism, antimicrobial defenses, epidermal differentiation and control of cutaneous vasculature. Cluster analysis of transcripts with significantly altered expression identified a group of genes involved in lipid metabolism with highly correlated gene expression. Promoter analysis demonstrated enrichment for binding sites of three transcription factors; peroxisome proliferator-activator receptor alpha (PPARA), sterol regulatory element-binding protein (SREBF) and estrogen receptor 2 (ESR2), suggesting that coordinate regulation of lipid metabolic genes may be related to the action of these factors. Taken together, our results identify a “pre-psoriatic” gene expression signature, suggesting decreased lipid biosynthesis and increased innate immunity in uninvolved psoriatic skin.
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影响因子：
3.5
作者：
Bowcock, AM;Shannon, W;Menter, A
通讯作者：
Menter, A
影响因子：
82.9
作者：
Conrad, Curdin;Boyman, Onur;Nestle, Frank O.
通讯作者：
Nestle, Frank O.
DOI：
10.1016/s0950-3579(94)80024-3
发表时间：
1994-05-01
期刊：
BAILLIERES CLINICAL RHEUMATOLOGY
影响因子：
--
作者：
GLADMAN, DD
通讯作者：
GLADMAN, DD
影响因子：
4.7
作者：
Kulski, JK;Kenworthy, W;Inoko, H
通讯作者：
Inoko, H
DOI：
10.1038/jid.2008.266
发表时间：
2009-03
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
通讯作者：
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