Expression of BLT1 leukotriene B4 receptor on the dorsal root ganglion neurons in mice
Expression of BLT1 leukotriene B4 receptor on the dorsal root ganglion neurons in mice
复制标题
DOI：
10.1016/j.molbrainres.2005.02.029
复制
发表时间：
2005-06-13
期刊：
影响因子：
--
通讯作者：
Kuraishia, Y
中科院分区：
文献类型：
--
作者：
Andoh, T;Kuraishia, Y
我们用小鼠研究背根神经节（DRG）神经元是否表达白三烯134受体。BLT 1受体mRNA在DRG中表达，而BLT 2受体mRNA在DRG中不表达。白三烯B-4可使培养的DRG神经元胞内Ca ~（2+）浓度升高，而白三烯B-4拮抗剂可抑制这种作用。许多BLT 1免疫反应阳性神经元体积小，TRPV 1阳性。BLT 1免疫反应性纤维存在于皮肤中。结果表明，功能性BLT 1受体的感觉神经元的表达。(c)2005 Elsevier B. V.保留所有权利。
We investigated using mice whether dorsal root ganglion (DRG) neurons express leukotriene 134 receptors. BLT1, but not BLT2, receptor mRNA was expressed in the DRG. Leukotriene B-4 increased intracellular Ca2+ concentration in cultured DRG neurons, which was inhibited by leukotriene B-4 antagonist. Many BLT1-immunoreactive neurons were small in size and positive for TRPV1. BLT1-immunoreactive fibers are present in the skin. The results suggest the expression of functional BLT1 receptors in the sensory neurons. (c) 2005 Elsevier B.V. All rights reserved.