Combined high-resolution magnetic resonance imaging and histological examination to explore the role of ligaments and tendons in the phenotypic expression of early hand osteoarthritis
Combined high-resolution magnetic resonance imaging and histological examination to explore the role of ligaments and tendons in the phenotypic expression of early hand osteoarthritis
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DOI：
10.1136/ard.2005.050112
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发表时间：
2006-10-01
影响因子：
27.4
通讯作者：
McGonagle, D.
中科院分区：
文献类型：
--
作者：
Tan, A. L.;Toumi, H.;McGonagle, D.
背景资料：手骨关节炎的早期阶段的发病机制是知之甚少，但最近的高分辨率磁共振成像（hrMRI）的研究表明，关节韧带有一个主要的作用，在疾病的表型expressions.Objective：联合收割机和尸体的组织学研究，以更好地了解损伤的机制，特别是关节韧带和肌腱在疾病的表达中的作用。研究方法：对20例骨关节炎患者的远端指间关节（DIP）和近端指间关节（PIP）进行hrMRI检查，
Background: The pathogenesis of the early stages of hand osteoarthritis is poorly understood, but recent high-resolution magnetic resonance imaging (hrMRI) studies suggest that the joint ligaments have a major role in the phenotypic expression of the disease.Objective: To combine hrMRI and cadaveric histological studies to better understand the mechanisms of damage, and especially the role of joint ligaments and tendons in disease expression. Methods: hrMRI was carried out in the distal interphalangeal (DIP) and proximal interphalangeal (PIP) joints in 20 patients with osteoarthritis, with a disease duration