Functional magnetic nanoparticles for medical application
Functional magnetic nanoparticles for medical application
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DOI：
10.1016/j.jmmm.2006.11.083
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发表时间：
2007-03-01
影响因子：
2.7
通讯作者：
Setou, Mitsutoshi
中科院分区：
文献类型：
--
作者：
Ichiyanagi, Yuko;Moritake, Shinji;Setou, Mitsutoshi
我们通过氨基-硅烷偶联的方法制备了氨基取代的纳米粒子。原始磁性颗粒是γ-Fe 2 O3，其尺寸范围为1.3至34 nm，被无定形SiO2包围。使用傅里叶变换红外分光光度计（FT-IR）确认通过添加氨基对磁性颗粒的改性。X射线衍射图谱显示改性前后均为尖晶石结构。氨基的阳离子。磁化曲线表明在室温下3 nm颗粒的顺磁性行为，7 nm颗粒的超顺磁性行为，和9 nm颗粒的铁磁性行为。将荧光试剂施加到颗粒上，并将颗粒引入细胞中。使用外部磁场定位细胞中的磁性颗粒。(C)2006 Elsevier B. V.保留所有权利。
We prepared an amino-substituted nanoparticle by means of the amino-silane coupling procedure. The original magnetic particles were gamma-Fe2O3, which ranged in size from 1.3 to 34 nm, surrounded by amorphous SiO2. The modification of the magnetic particle by the addition of an amino group was confirmed using a Fourier transform infrared spectrophotometer (FT-IR). The X-ray diffraction patterns showed a spinel structure both before and after modi. cation of the amino group. The magnetization curve indicated paramagnetic behavior for the 3 nm particles, superparamagnetic behavior for the 7 nm particles, and ferromagnetic behavior for 9 nm particles at room temperature. A fluorescent reagent was applied to the particle, and the particle was introduced into a cell. The magnetic particles in the cell were localized using an external magnetic field. (C) 2006 Elsevier B.V. All rights reserved.