Ultrasonic enhancement of drug penetration in solid tumors.
Ultrasonic enhancement of drug penetration in solid tumors.
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DOI：
10.3389/fonc.2013.00204
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发表时间：
2013
影响因子：
4.7
通讯作者：
Ferrara KW
中科院分区：
文献类型：
--
作者：
Lai CY;Fite BZ;Ferrara KW
提高药物在实体肿瘤中的渗透率可以通过多种超声介导的机制来实现。超声波的应用可以直接改变组织的结构或生理，也可以引起药物或载体的变化，以提高递送和疗效。对于每个超声波脉冲，传播波中的一小部分能量被组织吸收，并导致局部加热。当应用超声波来实现轻度热疗时，热效应与灌注量的增加或药物从温度敏感的载体释放有关。较高的超声强度会局部消融组织，并导致消融区域周围药物积聚增加。此外，超声脉冲引起的机械位移会导致气泡的形核、长大和坍塌。作为这种空化的结果，可以增加管壁或细胞膜的渗透性。最后，传播脉冲的辐射压力可以平移粒子或组织。从这个角度出发，我们将回顾超声介导的肿瘤传递的最新进展和临床移植的机会。
Increasing the penetration of drugs within solid tumors can be accomplished through multiple ultrasound-mediated mechanisms. The application of ultrasound can directly change the structure or physiology of tissues or can induce changes in a drug or vehicle in order to enhance delivery and efficacy. With each ultrasonic pulse, a fraction of the energy in the propagating wave is absorbed by tissue and results in local heating. When ultrasound is applied to achieve mild hyperthermia, the thermal effects are associated with an increase in perfusion or the release of a drug from a temperature-sensitive vehicle. Higher ultrasound intensities locally ablate tissue and result in increased drug accumulation surrounding the ablated region of interest. Further, the mechanical displacement induced by the ultrasound pulse can result in the nucleation, growth and collapse of gas bubbles. As a result of such cavitation, the permeability of a vessel wall or cell membrane can be increased. Finally, the radiation pressure of the propagating pulse can translate particles or tissues. In this perspective, we will review recent progress in ultrasound-mediated tumor delivery and the opportunities for clinical translation.