ESTERIFICATION OF N-PROTECTED ALPHA-AMINO-ACIDS WITH ALCOHOL/CARBODIIMIDE/4-(DIMETHYLAMINO)-PYRIDINE - RACEMIZATION OF ASPARTIC AND GLUTAMIC-ACID DERIVATIVES
ESTERIFICATION OF N-PROTECTED ALPHA-AMINO-ACIDS WITH ALCOHOL/CARBODIIMIDE/4-(DIMETHYLAMINO)-PYRIDINE - RACEMIZATION OF ASPARTIC AND GLUTAMIC-ACID DERIVATIVES
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DOI：
10.1021/jo00349a028
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发表时间：
1982-01-01
影响因子：
3.6
通讯作者：
RAMASAMY, K
中科院分区：
文献类型：
--
作者：
DHAON, MK;OLSEN, RK;RAMASAMY, K
G. W.安德森；F. M. J.卡拉汉。化学。社会科学，1960,82,3359。6所有的油在硅胶60上用正己烷-丙酮（9:1）用mplc纯化。c气相色谱分析通过水解（6 Nhc1, 100℃，24 h）进行，然后衍生为/ v -三氟乙酰异丙酯，并在光学活性毛细管柱上分析（见参考文献9）。比纳特，j.f.；Rzeszotarska b;贾斯特斯·李比希斯·安。化学，1961,646,123。®Lit. mp 44-45 C（见参考文献），f Mijoric，。p .诉;沃克，j.j. Org。化学，1960,25,909。* litp 43- 44c（参见参考文献）. 6相应的n保护氨基酸与重氮甲烷在醚-甲醇中酯化制备的酯的旋转。杜塔,;Morley， G. SJ Chem。Soc。C 1971, 2896。1
0 Anderson, G. W.; Callahan, F. M. J. Am. Chem. Soc. 1960, 82, 3359. 6 All oils were purified byMPLC on silica gel 60 with hexane-acetone (9: 1). c Gas chromatographic analysis was carried out by hydrolysis (6 Nhc1, 100 C, 24 h), followed by derivatization as the/V-trifluoroacetyl isopropyl esters and analysis on an optically active capillary column (see ref 9). d Tashner, VE; Biernat, J. F.; Rzeszotarska, B.; Wasielewski, C. Justus Liebigs Ann. Chem. 1961, 646, 123.® Lit. mp 44-45 C (see ref a), f Mijoric,. P. V.; Walker, J. J. Org. Chem. 1960, 25, 909.* Lit. mp 43-44 C (see ref f). 6 Ro-tation of ester prepared by esterification of the corresponding N-protected amino acid with diazomethane in ether-meth-anol.! Dutta, AS; Morley, G. SJ Chem. Soc. C 1971, 2896. 1