Frequency and presentation of neuroleptic malignant syndrome in a large psychiatric hospital.
Frequency and presentation of neuroleptic malignant syndrome in a large psychiatric hospital.
复制标题
大型精神病医院抗精神病药恶性综合征的频率和表现。
DOI：
10.1176/ajp.143.10.1227
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
McElroy,SL
中科院分区：
文献类型：
--
作者：
PopeJr,HG;KeckJr,PE;McElroy,SL
抗精神病药物恶性综合征是一种危险但鲜为人知的抗精神病药物并发症，通常被认为是罕见的。为了评估该综合征在大型精神病医院的发生率，作者首先回顾了文献并制定了操作诊断标准。使用这些标准调查近500名在1年期间接受抗精神病药物治疗的患者，他们发现7名（1.4%）经历了明确或可能的抗精神病药物恶性综合征。在几例病例中，包括一例致死性病例，没有立即考虑神经阻滞剂恶性综合征的诊断。作者得出结论，抗精神病药恶性综合征可能比以前认为的更常见，并且可能被低估。
Neuroleptic malignant syndrome, a dangerous but little-known complication of antipsychotic drugs, is often assumed to be rare. To assess the frequency of the syndrome in a large psychiatric hospital, the authors first reviewed the literature and developed operational diagnostic criteria. Using these criteria to survey nearly 500 neuroleptic-treated patients admitted during a 1-year period, they found that seven (1.4%) had experienced definite or probable neuroleptic malignant syndrome. In several cases, including one fatal case, the diagnosis of neuroleptic malignant syndrome was not immediately considered. The authors conclude that neuroleptic malignant syndrome may be more common than previously thought and may be underdiagnosed.