Cu2-xSe Nanocrystals with Localized Surface Plasmon Resonance as Sensitive Contrast Agents for In Vivo Photoacoustic Imaging: Demonstration of Sentinel Lymph Node Mapping
Cu2-xSe Nanocrystals with Localized Surface Plasmon Resonance as Sensitive Contrast Agents for In Vivo Photoacoustic Imaging: Demonstration of Sentinel Lymph Node Mapping
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DOI：
10.1002/adhm.201200388
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发表时间：
2013-07-01
影响因子：
10
通讯作者：
Swihart, Mark T.
中科院分区：
文献类型：
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作者：
Liu, Xin;Law, Wing-Cheung;Swihart, Mark T.
纳米材料的独特性质为克服当前医学障碍提供了许多机会。[1]例如，超顺磁性氧化铁[2，3]或螯合钆[4，5]纳米颗粒可以增强磁共振成像（MRI）的灵敏度，促进成像引导治疗。用于生物医学成像的光学纳米探针在过去十年中发展迅速。[6-8]特别是，镉基半导体纳米晶体（NC，也称为量子点或QD）已广泛用于体外和体内生物医学成像。然而，纯光学体内成像技术的浅穿透深度和有限的三维空间分辨率限制了它们相关的临床应用范围。[9-11]大多数组织在可见波长（480-650 nm）处表现出较强的光吸收和散射。因此，在近红外（NIR）区域（650-950 nm）中操作的光学纳米探针对于在组织中实现更深的成像是非常感兴趣的。[1]在这里，我们展示了前哨淋巴结的高对比度成像，这对癌症进展和转移的诊断非常重要，并且将从改进的成像技术中受益匪浅。
The unique properties of nanomaterials provide many opportunities to overcome current obstacles in medicine.[1] For example, super-paramagnetic iron oxide [2, 3] or chelated-gadolinium [4, 5] nanoparticles can enhance the sensitivity of magnetic resonance imaging (MRI), facilitating imaging-guided therapy. Optical nanoprobes for biomedical imaging have developed rapidly over the past decade.[6–8] In particular, cadmium-based semiconductor nanocrystals (NCs, also called quantum dots, or QDs) have been widely used for in vitro and in vivo biomedical imaging. However, the shallow penetration depth and limited three-dimensional spatial resolution of purely optical in vivo imaging techniques limits the range of clinical applications to which they are relevant.[9–11] Most tissues exhibit strong light absorption and scattering at visible wavelengths (480–650 nm). Therefore, optical nanoprobes operating in the near-infrared (NIR) region (650–950 nm) are of great interest for achieving deeper imaging in tissues.[1] Here we demonstrate high contrast imaging of sentinel lymph nodes, which is very important for diagnosis of cancer progression and metastasis, and which would benefit tremendously from improved imaging technologies.