INFLUENCE OF ETHANOL-CONSUMPTION ON NATURAL-KILLER CELL-ACTIVITY IN MICE
INFLUENCE OF ETHANOL-CONSUMPTION ON NATURAL-KILLER CELL-ACTIVITY IN MICE
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DOI：
10.1111/j.1530-0277.1989.tb00359.x
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发表时间：
1989-08-01
期刊：
影响因子：
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通讯作者：
DUNCAN, DD
中科院分区：
文献类型：
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作者：
MEADOWS, GG;BLANK, SE;DUNCAN, DD
酒精是一种已知的免疫系统抑制剂，酗酒者经常损害体液和细胞介导的免疫。一些研究表明，酒精调节自然杀伤细胞（NK）的活性。NK细胞对某些传染性疾病，自发产生的肿瘤，特别是血液传播的转移性肿瘤细胞提供重要的防御。酒精对NK细胞影响的评估因许多因素而复杂，包括：酒精滥用的水平和持续时间、多种药物的使用、受试者的年龄、营养和健康状况。本研究检测了1周和2周饮酒对基线和白细胞介素2 （IL-2）刺激小鼠NK细胞活性的影响。营养良好的雌性C57BL/6小鼠连续获得20% w/v的乙醇作为唯一的液体来源，并消耗约40%的总热量摄入为乙醇。实验1周和2周后，乙醇摄入组脾基线和IL-2刺激NK细胞活性显著低于对照组。实验动物的平均每日乙醇摄入量、血液酒精浓度和乙醇来源的卡路里百分比与NK细胞活性降低无关；也没有任何其他测量参数似乎作为乙醇调节脾NK细胞活性的指标。目前尚不清楚这种免疫抑制是由乙醇的“直接”调节还是间接因素引起的。
Alcohol is a known suppressant to the immune system, and alcoholics frequently have impaired humoral and cell-mediated immunity. Several studies indicate that alcohol modulates natural killer (NK) cell activity. NK cells provide important defense against certain infectious diseases, spontaneously arising tumors and, in particular, to blood-borne metastasing tumor cells. Evaluation of the effects of alcohol on NK cells is complicated by many factors including: the level and duration of alcohol abuse, polydrug use, the subject''s age, and nutritional and health status. This study examined the effects of 1 and 2 weeks of alcohol consumption on baseline and interleukin 2 (IL-2) stimulated murine NK cell activity. Well nourished female C57BL/6 mice were given continuous access to 20% w/v ethanol as the sole fluid source and consumed about 40% of their total caloric intake as ethanol. Splenic baseline and IL-2 stimulated NK cell activity were significantly lower in ethanol-consuming groups compared to control groups after the 1- and 2-week test period. The average daily intake of ethanol, blood alcohol concentration, and the percentage of ethanol-derived calories were not associated with the decreased NK cell activity of the experimental animals; nor did any other measured parameter appear to serve as an indicator of ethanol modulation of splenic NK cell activity. Whether this immunosuppression results from the "direct" modulation of ethanol or from indirect factors is presently unknown.