Exercise-induced increase in hydrogen peroxide plasma levels is diminished by endurance training after myocardial infarction
Exercise-induced increase in hydrogen peroxide plasma levels is diminished by endurance training after myocardial infarction
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DOI：
10.1016/s0167-5273(98)00231-9
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发表时间：
1998-12-31
影响因子：
3.5
通讯作者：
Wysocki, H
中科院分区：
文献类型：
--
作者：
Deskur, E;Przywarska, I;Wysocki, H
我们研究了运动训练对心肌梗死患者运动诱发的自由基活性变化的影响。17名心脏康复中心的患者在3周耐力训练计划前后进行了自行车测力计测试。在试验过程中测量氧消耗和二氧化碳产生，并监测ECG和全身血压。在每次运动试验之前和之后直接收集血液样本用于酸碱平衡、乳酸水平和过氧化氢浓度。运动引起的收缩压，心率和心率-血压乘积以及乳酸浓度的增加在康复计划后进行的自行车测力计中显着降低。在最初的运动试验中，过氧化氢水平从试验前的7.15 +/- 0.74 μ mol/l显著增加到试验后3分钟的9.09 +/- 1.04 μ mol/l（P = 0.0229）。相反，在训练后进行的运动试验期间，未观察到过氧化氢浓度的显著变化（试验前为6.31 +/- 1.05 μ mol/l，试验后为5.85 +/- 1.08 μ mol/l，P = 0.201）。这些观察结果表明，体育锻炼可能对心肌梗死后患者的自由基产生有有益的影响。(C)1998爱思唯尔科学爱尔兰有限公司保留所有权利。
We have investigated the influence of physical training on exercise-induced changes in free radical activity in patients after myocardial infarction. Seventeen patients admitted to the cardiac rehabilitation center performed a bicycle ergometry before and after a 3-week endurance training program. The oxygen consumption and carbon dioxide production were measured and the ECG and the systemic blood pressure were monitored during the tests. Blood samples for acid-base equilibrium, lactic acid levels and hydrogen peroxide concentrations were collected directly before and after each exercise test. Exercise-induced increases in systolic blood pressure, heart rate and rate-pressure product as well as lactic acid concentrations were significantly less marked during the bicycle ergometry performed after the rehabilitation program. During the initial exercise test hydrogen peroxide levels increased significantly from 7.15 +/- 0.74 mu mol/l before to 9.09 +/- 1.04 mu mol/l 3 min after the test (P = 0.0229). In contrast, no significant changes in hydrogen peroxide concentrations were observed during the exercise test performed after the training (6.31 +/- 1.05 mu mol/l before the test, 5.85 +/- 1.08 mu mol/l after the test, P = 0.201). These observations suggest that physical training may have a beneficial influence on free radicals' generation in patients after myocardial infarction. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.