Cerebral ventricular change over the first 10 years after the onset of schizophrenia
Cerebral ventricular change over the first 10 years after the onset of schizophrenia
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DOI：
10.1016/j.pscychresns.2003.08.004
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发表时间：
2004-01-15
影响因子：
2.3
通讯作者：
Hoff, AL
中科院分区：
文献类型：
--
作者：
DeLisi, LE;Sakuma, M;Hoff, AL
精神分裂症患者的大脑结构异常是否具有进行性尚存争议。我们之前报道了一项对50名首发精神分裂症患者和20名对照患者的纵向研究，这些患者在患病的前5年进行了连续MRI扫描。与对照组相比，随着时间的推移，观察到患者侧脑室更大，半球体积减少。本研究对其中26名患者和10名对照患者进行了MRI扫描，随访时间为首次评估后的10年。第一次，第4-5年和第10年的扫描检查了脑室和半球体积的变化程度。与对照组相比，患者队列在第二个5年检测到显著更大的心室增大(P
Whether the brain structural abnormalities seen in schizophrenia are progressive is controversial. We previously reported on a longitudinal study of 50 first-episode patients with schizophrenia and 20 controls who had serial MRI scans during the first 5 years of illness. Greater enlargement of lateral ventricles and reduction of hemispheric volume was observed over time in the patients compared with controls. The present study obtained MRI scans from 26 of these patients and 10 controls at a follow-up 10 years subsequent to their first evaluations. The initial, 4-5th and 10th year scans were examined for the degree of change in ventricular and hemispheric volume. Significantly greater ventricular enlargement during the second 5 years was detected in the patient cohort compared with controls (P