New onset acute symptomatic seizure and risk factors in coronavirus disease 2019: A retrospective multicenter study
New onset acute symptomatic seizure and risk factors in coronavirus disease 2019: A retrospective multicenter study
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2019年冠状病毒病新发急性症状性癫痫发作及危险因素：一项回顾性多中心研究
DOI：
10.1111/epi.16524
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发表时间：
2020-05-02
期刊：
影响因子：
5.6
通讯作者：
Zhou, Dong
中科院分区：
文献类型：
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作者：
Lu, Lu;Xiong, Weixi;Zhou, Dong
我们的目的是阐明2019冠状病毒病（COVID-19）患者急性症状性癫痫发作的发生率和风险。这项多中心回顾性研究招募了2020年1月18日至2月18日在中国疫情中心湖北省、四川省和重庆市的42家政府指定医院接受治疗的COVID-19患者。数据收集的医疗记录，由11名神经科医生使用标准的病例报告表。共有304人参加，其中108人病情严重。该队列中无已知癫痫病史。未观察到急性症状性癫痫发作或癫痫持续状态。两人在住院期间因急性应激反应和低钙血症而出现类似癫痫的症状，84人（27%）在疾病过程中出现脑损伤或代谢失衡，已知会增加癫痫发作的风险。没有证据表明COVID-19患者出现急性症状性癫痫发作的额外风险。病毒和癫痫发作的潜在风险因素似乎都不是COVID-19中急性症状性癫痫发作发生的重大风险。
Our aim was to clarify the incidence and risk of acute symptomatic seizures in people with coronavirus disease 2019 (COVID-19). This multicenter retrospective study enrolled people with COVID-19 from January 18 to February 18, 2020 at 42 government-designated hospitals in Hubei province, the epicenter of the epidemic in China; Sichuan province; and Chongqing municipality. Data were collected from medical records by 11 neurologists using a standard case report form. A total of 304 people were enrolled, of whom 108 had a severe condition. None in this cohort had a known history of epilepsy. Neither acute symptomatic seizures nor status epilepticus was observed. Two people had seizurelike symptoms during hospitalization due to acute stress reaction and hypocalcemia, and 84 (27%) had brain insults or metabolic imbalances during the disease course known to increase the risk of seizures. There was no evidence suggesting an additional risk of acute symptomatic seizures in people with COVID-19. Neither the virus nor potential risk factors for seizures seem to be significant risks for the occurrence of acute symptomatic seizures in COVID-19.