Field trial with oral vaccination of dogs against rabies in the Philippines
Field trial with oral vaccination of dogs against rabies in the Philippines
复制标题
DOI：
10.1186/1471-2334-1-23
复制
发表时间：
2001-11-28
影响因子：
3.7
通讯作者：
Mueller, T
中科院分区：
文献类型：
--
作者：
Estrada, R;Vos, A;Mueller, T
背景：在菲律宾，从安全性和有效性角度对狗口服狂犬病疫苗的潜在作用进行了调查。方法：在疫苗接种活动之前，进行了挨家挨户的调查，收集研究地区民都洛岛沿海村庄狗群的数据。在疫苗接种活动期间，再次走访了所有家庭，并在可能的情况下对遇到的所有狗（> 2 个月大）进行了疫苗接种。此外，14只接种疫苗的狗在不同场合被放血。结果：在调查期间，总共统计了216只狗，这些动物以前都没有接种过狂犬病疫苗。只有17只狗可以被限制住，随后由接种人员直接接种疫苗。另外126只狗被提供了本地制作的煮肠诱饵，其中含有一个装有3.0毫升SAD B19（10（7.9）FFU/毫升）的胶囊。狗对诱饵的接受率为96.1%。根据直接接种疫苗的动物数量和接受诱饵并随后刺破疫苗容器的狗数量估算，狗群（> 2月龄）的疫苗接种覆盖率为76%。疫苗接种后第 15 天和第 29 天，分别有 6 只和 10 只狗（n = 14）的狂犬病病毒中和抗体滴度大于或等于 0.5 IU/ml。没有报告包括人类在内的非目标物种与疫苗病毒无意接触的情况。结论：该活动的结果表明，给狗口服狂犬病疫苗是菲律宾控制狗狂犬病的一种很有前途的补充方法。
Background: The potential role of oral vaccination of dogs against rabies in the Philippines was investigated in terms of safety and efficacy.Methods: Prior to the vaccination campaign, a house-to-house survey was carried out to collect data on the dog population in the study area, the coastal village of Mindoro. During the vaccination campaign all households were visited again, and all dogs encountered (> 2 months old) were, if possible, vaccinated. Furthermore, 14 dogs vaccinated were bled on different occasions.Results: During the survey, a total of 216 dogs were counted, and none of these animals had previously been vaccinated against rabies. Only 17 dogs could be restrained and subsequently vaccinated directly by the vaccinators. Another 126 dogs were offered a local-made boiled intestine bait, containing a capsule filled with 3.0 ml SAD B19 (10(7.9) FFU/ml). The bait acceptance rate of dogs offered a bait was 96.1%. The vaccination coverage of the dog population ( > 2 months old) estimated by the number of animals vaccinated directly and the number of dogs that accepted a bait and subsequently punctured the vaccine container was 76%. Fi teen and 29 days after the vaccination campaign 6 and 10 dogs ( n = 14) had rabies virus neutralizing antibody titres of greater than or equal to 0.5 IU/ml, respectively. No unintentional contacts of nontarget species, including humans, with the vaccine virus were reported.Conclusions: The results of the campaign show that oral vaccination of dogs against rabies is a promising supplementary method in dog rabies control in the Philippines.