Presenting signs of retinoblastoma
Presenting signs of retinoblastoma
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DOI：
10.1016/s0022-3476(98)70028-9
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发表时间：
1998-03-01
影响因子：
5.1
通讯作者：
Boyd, NW
中科院分区：
文献类型：
--
作者：
Abramson, DH;Frank, CM;Boyd, NW
对1265例视网膜母细胞瘤患者的病历进行了回顾性病历审查，这些患者在纽约医院存档，其病情在1960年至1990年期间被诊断。平均随访90个月，范围从0到409个月。视网膜母细胞瘤有32种不同的表现，其中最常见的是白瞳（56.2%），斜视（23.6%），视力低下（7.7%）和家族史（6.8%）。没有发现任何表现体征与偏侧性性别、种族或生存率之间的相关性。白瞳与Reese-Ellsworth组Va或Vb相关，而斜视总是与黄斑肿瘤或黄斑视网膜脱离相关。83例（96.5%）有家族史的患者在24个月大之前就有家族史。导致视网膜母细胞瘤诊断的表现与肿瘤的进展程度和位置相关。白瞳和斜视是最常见的表现，白瞳与更晚期的疾病相关，斜视总是与黄斑受累相关。玻璃体出血（1例，0.1%），小眼球（4例，0.3%）和眼眶蜂窝织炎（3例，0.2%）是视网膜母细胞瘤中极为罕见的表现。
A retrospective chart review was performed on the charts of 1265 patients with retinoblastoma who were on file at New York Hospital and whose conditions had been diagnosed between the years 1960 and 1990. The mean follow-up was 90 months, ranging from 0 to 409 months. Thirty-two distinct presenting signs of retinoblastoma were identified, the most common of which were leukocoria (56.2%), strabismus (23.6%), poor vision (7.7%), and family history (6.8%). No correlation was found between any of the presenting signs and laterality sex, race, or survival. Leukocoria correlated to Reese-Ellsworth Group Va or Vb, whereas strabismus was invariably associated with either macular tumors or macular retinal detachments. Eighty-three (96.5%) patients presenting with a family history did so before the age of 24 months. The presenting sign leading to a diagnosis of retinoblastoma was correlated with degree of advancement and tumor location. Leukocoria and strabismus are the most common presenting signs, with leukocoria correlated to more advanced disease and strabismus always associated with macular involvement. Vitreous hemorrhage (1 case, 0.1%), microphthalmos (4 cases, 0.3%), and orbital cellulitis (3 cases, 0.2%) are extremely rare presenting findings in retinoblastoma.