Vancomycin for treatment of invasive, multi-drug resistant Staphylococcus aureus infections
Vancomycin for treatment of invasive, multi-drug resistant Staphylococcus aureus infections
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万古霉素用于治疗侵袭性、多重耐药金黄色葡萄球菌感染
DOI：
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发表时间：
2007
影响因子：
3.2
通讯作者：
Andrew M. Roecker
中科院分区：
文献类型：
--
作者：
Scott D. Pope;Andrew M. Roecker
金黄色葡萄球菌是引起多种严重感染的细菌病原体，并且是医院内疾病的常见原因。在过去的60年里，S。金黄色葡萄球菌已经对几乎所有的抗微生物剂产生了增加的体外抗性。相比之下，万古霉素在体外对该病原体保持高度活性，尽管体外活性的轻微变化可能极大地改变临床活性。因此，万古霉素已成为治疗甲氧西林耐药菌株所致侵袭性感染的主要药物。然而，临床菌株S. 1996年报告了对万古霉素具有中等耐药性的金黄色葡萄球菌，随后在2002年报告了完全耐药的分离株。尽管许多权威机构认为万古霉素仍然是大多数葡萄球菌耐药感染的首选药物，但其临床应用仍存在重要问题。这些包括需要每日多次给药、静脉给药、需要监测血清浓度、体外耐药性增加、适度的疗效率和（不太频繁）限制治疗的不良反应。本评论涉及这些重要主题。
Staphylococcus aureus is a bacterial pathogen responsible for a variety of serious infections and is a frequent cause of nosocomial disease. During the last 60 years, S. aureus has developed increasing in vitro resistance to virtually all antimicrobials. In contrast, vancomycin has maintained a high degree of activity in vitro against this pathogen, although slight changes with in vitro activity could vastly change clinical activity. As a result, vancomycin has become the mainstay of therapy for invasive infections due to methicillin-resistant strains. However, clinical strains of S. aureus with intermediate resistance to vancomycin were reported in 1996, followed in 2002 with reports of isolates that were fully resistant. Although many authorities believe vancomycin remains the drug of choice for most staphylococcal-resistant infections, important issues surrounding its clinical application remain. These include the need for multiple daily dosing, intravenous administration, requirements for serum concentration monitoring, increasing resistance in vitro, modest efficacy rates and (less frequently) treatment-limiting adverse effects. This review addresses these important topics.
未经选择的金黄色葡萄球菌临床分离株万古霉素敏感性连续下降的证据。
DOI：
10.1086/342708
发表时间：
2002
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Hussain,FaridM;Boyle-Vavra,Susan;Shete,PriyaB;Daum,RobertS
通讯作者：
Daum,RobertS
在旧金山湾区接受血液透析的患者中，金黄色葡萄球菌定植率较低，万古霉素敏感性降低。
DOI：
10.1086/429906
发表时间：
2005
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
影响因子：
--
作者：
Eguia,JoseM;Liu,Catherine;Moore,Matthew;Wrone,ElizabethM;Pont,Joan;Gerberding,JulieL;Chambers,HenryF
通讯作者：
Chambers,HenryF
影响因子：
158.5
作者：
Von Drygalski, Annette;Curtis, Brian R.;Aster, Richard H.
通讯作者：
Aster, Richard H.