A QUANTITATIVE ASSESSMENT OF THE ADDITION OF MRI TO CT-BASED, 3-D TREATMENT PLANNING OF BRAIN-TUMORS
A QUANTITATIVE ASSESSMENT OF THE ADDITION OF MRI TO CT-BASED, 3-D TREATMENT PLANNING OF BRAIN-TUMORS
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DOI：
10.1016/0167-8140(92)90018-p
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发表时间：
1992-10-01
影响因子：
5.7
通讯作者：
MCSHAN, DL
中科院分区：
文献类型：
--
作者：
TENHAKEN, RK;THORNTON, AF;MCSHAN, DL
定量三维体积比较的复合CT-MRI宏观和微观肿瘤和目标体积，其独立定义的成分。还对来自冠状和轴向MRI数据集的体积之间以及在重复会话中重新定义的CT和MRI体积与其原始定义之间进行了体积比较。还分析了仅使用CT数据或仅使用MRI数据在复合CT-MRI体积覆盖方面获得的3-D剂量覆盖程度。平均而言，MRI定义了更大的体积以及更大份额的复合CT-MRI体积。平均而言，如果仅使用MRI数据，则块边缘增加约0.5 cm将确保覆盖使用两种成像模式得出的体积。然而，观察者间体积定义的变化程度与不同模式之间体积定义的差异程度相当，在进行详细的组织学研究之前，哪种成像模式最能描述肿瘤体积的问题仍然没有答案。考虑到CT和MRI上独立显示的肿瘤体积具有相同的有效性，计划时应考虑复合CT-MRI输入，以确保适形治疗的精确剂量覆盖。
Quantitative 3-D volumetric comparisons were made of composite CT-MRI macroscopic and microscopic tumor and target volumes to their independently defined constituents. Volumetric comparisons were also made between volumes derived from coronal and axial MRI data sets, and between CT and MRI volumes redefined at a repeat session in comparison to their original definitions. The degree of 3-D dose coverage obtained from use of CT data only or MRI data only in terms of coverage of composite CT-MRI volumes was also analyzed. On average, MRI defined larger volumes as well as a greater share of composite CT-MRI volumes. On average, increase s in block margin on the order of 0.5 cm would have ensured coverage of volumes derived from use of both imaging modalities had only MRI data been used. However, the degree of inter-observer variation in volume definition is on the order of the magnitude of differences in volume definition seen between the modalities, and the question of which imaging modality best describes tumor volumes remains unanswered until detailed histologic studies are performed. Given that tumor volumes independently apparent on CT and MRI have equal validity, composite CT-MRI input should be considered for planning to ensure precise dose coverage for conformal treatments.