Amphiepicoccins A-J: Epipolythiodioxopiperazines from the Fish-Gill-Derived Fungus Epicoccum nigrum HDN17-88.
Amphiepicoccins A-J: Epipolythiodioxopiperazines from the Fish-Gill-Derived Fungus Epicoccum nigrum HDN17-88.
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DOI：
10.1021/acs.jnatprod.9b01242
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发表时间：
2020-01
影响因子：
5.1
通讯作者：
Qiuying Wang;Kaijin Zhang;Wei Wang;Guojian Zhang;T. Zhu;Qian Che;Q. Gu;Dehai Li
中科院分区：
文献类型：
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作者：
Qiuying Wang;Kaijin Zhang;Wei Wang;Guojian Zhang;T. Zhu;Qian Che;Q. Gu;Dehai Li
从黑附球菌（Epicoccum nigrum HDN 17 -88）中分离得到10个新的表聚硫代二氧代哌嗪（epipolithiodioxopiperazines，ETP），即双表球菌素A-J（1-10）。通过大量的光谱数据和电子圆二色谱（ECD）计算，推测了它们的结构.在ETP中，含有芳香族吲哚基序的Amphiepicoccin A（1）是前所未有的。化合物1、3和6显示出抗HSV-2活性，IC 50值分别为70、64和29 μM（阿昔洛韦作为阳性对照，IC 50值为31 μM），而化合物5和6还显示出对枯草芽孢杆菌的抑制活性，最小抑制浓度（MIC）值分别为13和25 μM。
Ten new epipolythiodioxopiperazines (ETPs), namely, amphiepicoccins A-J (1-10), were isolated from the fish-gill-derived fungus Epicoccum nigrum HDN17-88. Their structures were deduced from extensive spectroscopic data and electronic circular dichroism (ECD) calculations. Amphiepicoccin A (1) which contains an aromatic indole motif is unprecedented among the epicoccin type of ETPs. Compounds 1, 3, and 6 displayed anti-HSV-2 activities, with IC50 values of 70, 64, and 29 μM, respectively (acyclovir as positive control with an IC50 value of 31 μM), while 5 and 6 also revealed inhibitory activity against Bacillus subtilis with minimum inhibitory concentration (MIC) values of 13 and 25 μM, respectively.