Oxidative stress and inflammation in obesity after taurine supplementation: a double-blind, placebo-controlled study
Oxidative stress and inflammation in obesity after taurine supplementation: a double-blind, placebo-controlled study
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DOI：
10.1007/s00394-013-0586-7
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发表时间：
2014-04-01
影响因子：
5
通讯作者：
Marchini, Julio Sergio
中科院分区：
文献类型：
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作者：
Rosa, Flavia Troncon;Freitas, Ellen Cristini;Marchini, Julio Sergio
一些研究人员发现，肥胖受试者和动物的血浆牛磺酸水平降低，牛磺酸合成的一种重要酶的表达减少。这些证据，加上肥胖的代谢失衡和牛磺酸可能的抗炎和抗氧化作用，突出了牛磺酸作为肥胖治疗补充剂的用途。本研究采用随机双盲安慰剂对照研究方法，对16名肥胖妇女和8名正常体重妇女进行了补充牛磺酸的营养咨询，以探讨补充牛磺酸是否能调节肥胖妇女的氧化应激、炎症反应和葡萄糖稳态。肥胖志愿者的年龄和体重指数相匹配，并随机分配到安慰剂（3克/天淀粉粉）或牛磺酸（3克/天牛磺酸）组。这项研究持续了8周，实验方案包括营养评估和血浆含硫氨基酸、胰岛素、脂联素、血清牛磺酸、炎症反应和氧化应激标志物的测定。肥胖志愿者的血浆牛磺酸水平显著降低（41%）。安慰剂组和牛磺酸组均显示体重显著减轻（3%），组间无差异。与安慰剂不同，补充牛磺酸组显示血浆牛磺酸（97%）和脂联素（12%）显著增加，炎症标记物hs-C-反应蛋白（29%）和脂质过氧化标记物硫代巴比妥酸反应物质（TBARS）（20%）显著降低八周的牛磺酸补充与营养咨询能够增加脂联素水平和减少炎症标志物，（高敏C反应蛋白）和脂质过氧化（TBARS）。
Some researchers found decreased levels of plasma taurine in obese subjects and animals, and reduced expression of an important enzyme of taurine synthesis. These evidences, coupled with the metabolic imbalance of obesity and the possible anti-inflammatory and antioxidant effects of taurine, highlighted the use of taurine as a supplement in obesity treatment. The aim of the present study was to investigate whether taurine supplementation, associated with nutritional counseling, modulates oxidative stress, inflammatory response, and glucose homeostasis in obese women.A randomized double-blind placebo-controlled study was conducted with 16 women with obesity diagnosis and 8 women in the normal weight range. The obese volunteers were matched by age and body mass index and randomly assigned to either the placebo (3 g/day starch flour) or taurine (3 g/day taurine) group. The study lasted 8 weeks, and the experimental protocol included nutritional assessment and determination of plasma sulfur amino acids, insulin, and adiponectin, serum glycemia, and markers of inflammatory response and oxidative stress.Plasma taurine levels were significantly decreased (41 %) in the obese volunteers. Both the placebo and taurine groups showed significant reduction in weight (3 %), with no differences between groups. Different from placebo, taurine-supplemented group showed significant increase in plasma taurine (97 %) and adiponectin (12 %) and significant reduction in the inflammatory marker hs-C-reactive protein (29 %) and in the lipid peroxidation marker thiobarbituric acid reactive substances (TBARS) (20 %).Eight weeks of taurine supplementation associated with nutritional counseling is able to increase adiponectin levels and to decrease markers of inflammation (high-sensitivity C-reactive protein) and lipid peroxidation (TBARS) in obese women.