Identification and Characterization of Multiple Myeloma Stem Cell-Like Cells.
Identification and Characterization of Multiple Myeloma Stem Cell-Like Cells.
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DOI：
10.3390/cancers13143523
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发表时间：
2021-07-14
期刊：
影响因子：
5.2
通讯作者：
Xiao X
中科院分区：
文献类型：
--
作者：
Guo W;Wang H;Chen P;Shen X;Zhang B;Liu J;Peng H;Xiao X
尽管多发性骨髓瘤（multiple myeloma， MM）肿瘤干细胞的存在存在争议，但大量研究表明，多发性骨髓瘤中有一类细胞比一般肿瘤细胞具有更强的增殖、迁移、成瘤性和耐药性，因此我们称其为多发性骨髓瘤干细胞样群体。因此，对这些细胞的定义、筛选和靶向抑制是非常重要的。本文列举了用于筛选MM干细胞样群体的标志物和MM治疗中相关抑制剂的研究，并介绍了MM中与干性相关的途径和这些途径的主要靶分子。多发性骨髓瘤（Multiple myeloma， MM）是一种发病率高、预后差的血液系统b细胞肿瘤。随着对MM发病机制和骨髓微环境的进一步了解，各种辅助细胞疗法和新药被开发出来。然而，MM的耐药和复发率高的问题并没有得到根本解决。研究表明，MM患者中存在一种低分化祖细胞（MM干细胞样细胞，MMSCs）。虽然没有公认的鉴定和分类标准，但已经证实它们与MM的耐药和复发密切相关。因此，本文系统地总结了MMSCs的最新进展和可能的MMSCs标记物，介绍了MMSCs在MM耐药和复发中的作用机制，并讨论了与MM干系相关的活性途径。
Although the existence of multiple myeloma (MM) cancer stem cells is controversial, a large number of studies have shown that there is a kind of cells in multiple myeloma that has stronger proliferation, migration, tumorigenesis, and drug resistance than general tumor cells, and so we call them the multiple myeloma stem cell-like population. Therefore, the definition, screening, and targeted inhibition of these cells are very important. In this paper, we list the markers used to screen the MM stem cell-like population and the research of related inhibitors in MM treatment and introduce the pathways related to stemness in MM and the main target molecules in these pathways. Multiple myeloma (MM) is a B-cell tumor of the blood system with high incidence and poor prognosis. With a further understanding of the pathogenesis of MM and the bone marrow microenvironment, a variety of adjuvant cell therapies and new drugs have been developed. However, the drug resistance and high relapse rate of MM have not been fundamentally resolved. Studies have shown that, in patients with MM, there is a type of poorly differentiated progenitor cell (MM stem cell-like cells, MMSCs). Although there is no recognized standard for identification and classification, it is confirmed that they are closely related to the drug resistance and relapse of MM. This article therefore systematically summarizes the latest developments in MMSCs with possible markers of MMSCs, introduces the mechanism of how MMSCs work in MM resistance and recurrence, and discusses the active pathways that related to stemness of MM.
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影响因子：
4
作者：
Feng, Yongdong;Wen, Jianguo;Chang, Chung-Che
通讯作者：
Chang, Chung-Che
DOI：
10.1158/1078-0432.ccr-16-2692
发表时间：
2017-08-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Das DS;Das A;Ray A;Song Y;Samur MK;Munshi NC;Chauhan D;Anderson KC
通讯作者：
Anderson KC
影响因子：
37.3
作者：
Ai, Lisha;Mu, Shidai;Hu, Yu
通讯作者：
Hu, Yu
影响因子：
10.1
作者：
Boutin, Laetitia;Arnautou, Pierre;Anginot, Adrienne
通讯作者：
Anginot, Adrienne
芳基碳氢化合物受体/细胞色素 P450 1A1 通路通过 PTEN 抑制以及 β-Catenin 和 Akt 激活介导乳腺癌干细胞扩增。
影响因子：
37.3
作者：
Al-Dhfyan A;Alhoshani A;Korashy HM
通讯作者：
Korashy HM