Fractionated doses of ionizing radiation alter postprandial small intestinal motor activity.
Fractionated doses of ionizing radiation alter postprandial small intestinal motor activity.
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分次剂量的电离辐射改变餐后小肠运动活动。
DOI：
10.1007/bf01296427
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发表时间：
1992
影响因子：
3.1
通讯作者：
Lee,MB
中科院分区：
文献类型：
--
作者：
Otterson,MF;Sarna,SK;Lee,MB
我们研究了全腹部分次辐照对5只狗餐后小肠运动活动的影响。在每只狗的十二指肠、空肠和回肠的血清肌层安装5个应变传感器，记录循环肌肉收缩情况。放疗（250 cGy）每周3次，隔天连续3周（总剂量2250 cGy）。在放疗期间以及放疗完成后的1周和3周，每周进行一次餐后4小时的记录。十二指肠收缩的平均幅度和面积在放疗期间和放疗后没有变化，但十二指肠收缩的平均频率和持续时间在放疗期间减少。放疗后这两个参数都恢复到基线值。辐射期间空肠收缩的平均持续时间、幅度、面积和频率降低；平均幅度和面积恢复到放疗后的基线值，但收缩的持续时间和频率没有恢复。放疗期间回肠收缩各项指标均有所下降，除面积和幅度外，其他指标均保持抑制。明显减少强度和频率的收缩，特别是在空肠和回肠发生照射期间和之后。这些变化可能会改变运输时间。
We investigated the effects of total abdominal fractionated irradiation on postprandial small intestinal motor activity in five dogs. Five strain-gauge transducers were attached to the seromuscular layer of the duodenum, jejunum, and ileum of each dog to record circular muscle contractions. Radiation (250 cGy) was administered three times a week on alternate days for three successive weeks (total dose, 2250 cGy). Postprandial 4-hr recordings were made once each week during radiation and at one and three weeks following completion of radiation. Duodenal mean amplitude and area under contractions did not change during or following the radiation schedule, but the mean frequency and duration of duodenal contractions decreased during the radiation schedule. Both parameters returned to baseline values postirradiation. Jejunal mean duration, amplitude, area, and frequency of contractions decreased during radiation; mean amplitude and area returned to baseline values postirradiation but not the duration and frequency of contractions. All parameters of ileal contractions decreased during radiation, and all but area and amplitudes remained depressed postirradiation. Significantly decreased strength and frequency of contractions, particularly in the jejunum and ileum occur during and following irradiation. These changes may potentially alter transit time.