Increased plasma glucose and insulin responses to high-carbohydrate feedings in normal subjects.
Increased plasma glucose and insulin responses to high-carbohydrate feedings in normal subjects.
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正常受试者对高碳水化合物喂养的血浆葡萄糖和胰岛素反应增加。
DOI：
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发表时间：
1974
影响因子：
5.8
通讯作者：
J. Olefsky
中科院分区：
文献类型：
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作者：
G. Reaven;J. Olefsky
本文测定了20名成年非糖尿病男性对两种不同饮食的血糖和胰岛素反应。饮食是等热量的，不同的热量，脂肪和碳水化合物。一种饮食含有42%的脂肪和43%的碳水化合物，而另一种饮食含有30%的脂肪和55%的碳水化合物。在每个饮食周期的第四粘土血浆葡萄糖和胰岛素水平测定之前，中午喂养，每小时为未来3 hr.The低脂高碳水化合物饮食导致餐后血糖和胰岛素浓度的增加。血糖反应的增加相对温和，但高碳水化合物饮食导致血浆胰岛素反应增加约40%。由于摄入低脂肪高碳水化合物饮食导致葡萄糖和胰岛素水平升高，因此必须重新考虑推荐此类饮食作为动脉粥样硬化性心脏病发展的一般预防措施的可行性。
ABSTRACT Plasma glucose and insulin responses to two different diets were measured in 20 adult nondiabetic men. The diets were isocaloric, and differed in amount of calories as fat and carbohydrate. One diet contained 42% fat and 43% carbohydrate, while the other contained 30% fat and 55% carbohydrate. On the fourth clay of each dietary period plasma glucose and insulin levels were measured before the noon feeding, and hourly for the next 3 hr. The low-fat–high-carbohydrate diet led to postprandial increases in plasma glucose and insulin concentrations. The increase in plasma glucose response was relatively modest, but the high-carbohydrate diet resulted in an approximate 40% increase in plasma insulin response. Since ingestion of a low-fat-high-carbohydrate diet led to increases in glucose and insulin levels, the advisability of recommending such diets as general prophylaxis against the development of atherosclerotic heart disease must be reconsidered in this light.