Neuromodulatory influence of norepinephrine during developmental experience-dependent plasticity.
Neuromodulatory influence of norepinephrine during developmental experience-dependent plasticity.
复制标题
去甲肾上腺素在发育经验依赖性可塑性过程中的神经调节影响。
DOI：
10.1152/jn.00461.2015
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发表时间：
2016
影响因子：
2.5
通讯作者：
Ward,NicholasJ
中科院分区：
文献类型：
--
作者：
Golovin,RandallM;Ward,NicholasJ
关键时期代表发育的阶段，在此期间，神经元回路及其反应可以很容易地被刺激塑造。在这些关键时期发生的依赖经验的可塑性可能会受到许多方面的影响；然而，Shepard等人。(J NeuroScience 35：2432-2437,2015)最近指出去甲肾上腺素是听觉皮质这种可塑性的重要驱动因素。这项工作为临界期可塑性的机制提供了新的见解，并挑战了先前的概念，即去甲肾上腺素和胆碱能对皮质可塑性的影响之间存在功能冗余。
Critical periods represent phases of development during which neuronal circuits and their responses can be readily shaped by stimuli. Experience-dependent plasticity that occurs within these critical periods can be influenced in many ways; however, Shepard et al. (J Neurosci35: 2432–2437, 2015) recently singled out norepinephrine as an essential driver of this plasticity within the auditory cortex. This work provides novel insight into the mechanisms of critical period plasticity and challenges previous conceptions that a functional redundancy exists between noradrenergic and cholinergic influences on cortical plasticity.