Shear stress-induced release of PGE(2) and PGI(2) by vascular smooth muscle cells
Shear stress-induced release of PGE(2) and PGI(2) by vascular smooth muscle cells
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DOI：
10.1006/bbrc.1996.1104
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发表时间：
1996-07-25
影响因子：
3.1
通讯作者：
Tarbell, JM
中科院分区：
文献类型：
--
作者：
Alshihabi, SN;Chang, YS;Tarbell, JM
本研究探讨了流体剪切应力对血管平滑肌细胞（SMC）生成血管介质PGE(2)和PGI(2)的直接影响。结果表明，剪切应力增加了SMC中PGE(2)和PGI(2)的释放。然而，PGE(2)和PGI(2)的生产模式不同。对于PGE(2)来说，剪切应力开始后的前三个小时，产量是中等的，然后在第4和第5小时之间急剧增加，在第6小时回到基础水平。另一方面，PGI(2)的生成速率在剪切开始后达到最大值，并在前三个小时保持升高。在接下来的三个小时里，这个速度趋于平稳，并保持在一个中等水平。结果还表明，SMC生产的PGI(2)比PGE(2)生产对剪切应力更敏感，因为0.5 dyne/cm(2)的水平产生最大的PGI(2)释放，而1 dyne/cm(2)的响应仅为20 dynes/cm(2)时PGE(2)的1/4。讨论了SMC流体剪切应力调节的生理意义。(C) 1996学术出版社，Inc.
This study addresses the direct effect of fluid how shear stress on production of the vascular mediators, PGE(2) and PGI(2) by vascular smooth muscle cells (SMC). Results indicate that shear stress increases PGE(2) and PGI(2) release in SMC. The production patterns, however, differ between PGE(2) and PGI(2). For PGE(2), the rate of production is moderate for the first three hours after the onset of shear stress, then dramatically increases between the fourth and fifth hours, returning to basal levels in the sixth hour. On the other hand, the rate for PGI(2), production is maximal right after the onset of shear and remains elevated for the first three hours. The rate then plateaus and remains at a moderate level during the next three hours. The results also indicate that SMC production of PGI(2) is more sensitive to shear stress than PGE(2) production since a level of 0.5 dynes/cm(2) produces a maximal PGI(2) release whereas 1 dyne/cm(2) produces only 1/4 the response seen at 20 dynes/cm(2) for PGE(2). The physiological implications of fluid shear stress regulation of SMC are discussed. (C) 1996 Academic Press, Inc.