Stem cells and nanomaterials.
Stem cells and nanomaterials.
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DOI：
10.1007/978-94-017-8739-0_13
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发表时间：
2014
影响因子：
--
通讯作者：
Hofmann MC
中科院分区：
文献类型：
--
作者：
Hofmann MC
由于其自我更新和分化为多种细胞类型的能力，干细胞提供了用于组织再生和工程的潜力。近年来，我们对干细胞生物学的理解以及我们操纵其增殖和分化以获得功能组织的能力取得了很大进展。同样，最近开发的纳米材料将加速发现驱动干细胞命运的机制及其在医学中的利用。已经开发了纳米颗粒，其允许标记和跟踪干细胞及其在生物体内的分化表型。纳米表面被设计成模拟干细胞粘附和迁移的细胞外基质。由功能化纳米纤维制成的支架现在可以用于培养干细胞和再生受损的组织和器官。然而，纳米材料的小尺度引起其化学和物理性质的变化，这可能会改变其与细胞和组织的相互作用，并使其对干细胞有毒。因此，对干细胞-纳米材料相互作用的深入了解仍然是必要的，不仅可以加速医学治疗的成功，而且可以确保这些新技术提供的工具的安全性。
Because of their ability to self-renew and differentiate into many cell types, stem cells offer the potential to be used for tissue regeneration and engineering. Much progress has recently been made in our understanding of the biology of stem cells and our ability to manipulate their proliferation and differentiation to obtain functional tissues. Similarly, nanomaterials have been recently developed that will accelerate discovery of mechanisms driving stem cell fate and their utilization in medicine. Nanoparticles have been developed that allow the labeling and tracking of stem cells and their differentiated phenotype within an organism. Nanosurfaces are engineered that mimic the extracellular matrix to which stem cells adhere and migrate. Scaffolds made of functionalized nanofibers can now be used to grow stem cells and regenerate damaged tissues and organs. However, the small scale of nanomaterials induces changes in their chemical and physical properties that might modify their interactions with cells and tissues, and render them toxic to stem cells. Therefore a thorough understanding of stem cell-nanomaterial interactions is still necessary not only to accelerate the success of medical treatments but also to ensure the safety of the tools provided by these novel technologies.