The nature of nurture: Effects of parental genotypes
The nature of nurture: Effects of parental genotypes
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DOI：
10.1126/science.aan6877
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发表时间：
2018-01-26
期刊：
影响因子：
56.9
通讯作者：
Stefansson, Kari
中科院分区：
文献类型：
--
作者：
Kong, Augustine;Thorleifsson, Gudmar;Stefansson, Kari
在遗传学研究中，父母基因组中没有遗传给孩子(先证者)的序列变异经常被忽略。在这里，我们展示了非传播等位基因可以通过对父母和其他亲属的影响来影响孩子，这种现象我们称之为“基因养育”。利用教育程度的Meta分析结果，我们发现，对21,637名至少有一位父母基因分型的先证者的非遗传等位基因计算的多基因得分对先证者的教育程度的估计效应是传递多基因得分的29.9%(P=1.6x10(-14))。这一多基因得分的遗传培育效应延伸到其他性状。父亲和母亲的多基因得分对教育程度的影响相似，但母亲在营养和健康相关特征上的贡献比父亲更大。
Sequence variants in the parental genomes that are not transmitted to a child (the proband) are often ignored in genetic studies. Here we show that nontransmitted alleles can affect a child through their impacts on the parents and other relatives, a phenomenon we call "genetic nurture." Using results from a meta-analysis of educational attainment, we find that the polygenic score computed for the nontransmitted alleles of 21,637 probands with at least one parent genotyped has an estimated effect on the educational attainment of the proband that is 29.9% (P = 1.6 x 10(-14)) of that of the transmitted polygenic score. Genetic nurturing effects of this polygenic score extend to other traits. Paternal and maternal polygenic scores have similar effects on educational attainment, but mothers contribute more than fathers to nutrition-and heath-related traits.