Consumption of mung bean (Vigna radiata L.) attenuates obesity, ameliorates lipid metabolic disorders and modifies the gut microbiota composition in mice fed a high-fat diet
Consumption of mung bean (Vigna radiata L.) attenuates obesity, ameliorates lipid metabolic disorders and modifies the gut microbiota composition in mice fed a high-fat diet
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DOI：
10.1016/j.jff.2019.103687
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发表时间：
2020-01-01
影响因子：
5.6
通讯作者：
Shen, Qun
中科院分区：
文献类型：
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作者：
Hou, Dianzhi;Zhao, Qingyu;Shen, Qun
绿豆被证明有几种健康益处，但人们对绿豆对高脂饮食(HFD)诱导的肥胖的影响或与肠道微生物区系组成变化的关系知之甚少。在此，观察到，食用HFD和30%熟绿豆(w/w)12周有效地缓解了体重增加和脂代谢紊乱，并伴随着肝脏脂肪变性和脂肪细胞体积的减少。此外，16S rRNA的高通量测序显示，绿豆的添加阻止了HFD诱导的肠道微生物区系失调，这可能与依赖HFD的几个分类群(瘤胃菌属9、穆氏杆菌属、毕氏菌属、布鲁氏菌属、瘤胃菌属和臭杆菌属)的相对丰度降低有关，而与Norank_f_Muribaculaceae的相对丰度增加有关。Spearman相关分析表明，这些属与肥胖相关指标密切相关。总的来说，补充绿豆对肥胖的预防作用至少部分是通过肠道微生物区系的结构调节来实现的。
Mung bean is shown having several health benefits, but a little bit of knowledge is known about its effects on high-fat diet (HFD)-induced obesity or its relationship with gut microbiota composition changes. Here, it was observed that consumption of HFD supplemented with cooked mung bean (30%, w/w) for 12 weeks effectively alleviated body weight gain and lipid metabolic disorders, which was accompanied by a decrease in hepatic steatosis and adipocyte size. Furthermore, high-throughput sequencing of 16S rRNA revealed that mung bean supplementation prevented the HFD-induced gut microbiota dysbiosis, which was likely associated with the decreased relative abundance of several HFD-dependent taxa (Ruminiclostridium_9, Mucispirillum, Bilophila, Blautia, Ruminiclostridium, and Odoribacter), and the increased relative abundance of norank_f_Muribaculaceae. Spearman's correlation analysis indicated that those genera were closely correlated with obesity-related indices. Collectively, the prevention of obesity by mung bean supplementation was at least partially mediated by structural modulation of gut microbiota.