QUANTITATIVE-EVALUATION OF THE EFFECT OF LOW-INTENSITY EXERCISE ON INSULIN-SECRETION IN MAN
QUANTITATIVE-EVALUATION OF THE EFFECT OF LOW-INTENSITY EXERCISE ON INSULIN-SECRETION IN MAN
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DOI：
10.1016/0026-0495(93)90054-r
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发表时间：
1993-07-01
影响因子：
9.8
通讯作者：
POLONSKY, KS
中科院分区：
文献类型：
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作者：
LEVITT, NS;HIRSCH, L;POLONSKY, KS
我们研究了 12 名正常受试者低强度运动（40% 峰值有氧能力 [Vo2]）期间的胰岛素分泌率 (ISR)，以评估胰岛素分泌改变对运动相关外周胰岛素浓度降低的影响。 ISR 是通过先前验证的外周 C 肽浓度两室分析方法计算的，该方法使用推注生物合成人 C 肽后推导出的各个参数。此外，还评估了低强度运动对C肽动力学参数的影响。结果表明，低强度运动并没有显着影响C肽动力学。在整个运动过程中，外周胰岛素浓度和 ISR 下降程度相似。血清胰岛素浓度平均最大下降，从基础值 42 ± 5.4 pmol/L 降至 24 ± 2.6 pmol/L，下降 51% ± 5.9% (P< .001)，ISR 从 85.7 ± 11.9 pmol/min 降至最低 45.6 ± 10.6 pmol/min (P< .001)，下降 48% ± 8.4%。血浆葡萄糖和胰高血糖素浓度在运动期间或运动后没有显着变化，尽管葡萄糖利用率和处置率相应增加两倍。我们认为运动期间外周胰岛素浓度的降低是由于胰岛素分泌减少所致。
We studied insulin secretion rates (ISR) during low-intensity exercise (40% peak aerobic capacity [Vo2]) in 12 normal subjects to assess the contribution of altered insulin secretion to the reduction in peripheral insulin concentrations associated with exercise. ISR were calculated by a previously validated method of two-compartment analysis of peripheral C-peptide concentrations using individual parameters derived following a bolus injection of biosynthetic human C-peptide. In addition, the effect of low-intensity exercise on kinetic parameters of C-peptide was evaluated. The results showed that low-intensity exercise did not significantly affect C-peptide kinetics. Peripheral insulin concentrations and ISR decreased to a similar degree throughout exercise. There was a mean maximum decrease in serum insulin concentrations from 42 ± 5.4 pmol/L basally to 24 ± 2.6 pmol/L, constituting a 51% ± 5.9% decrease (P< .001), and ISR decreased from 85.7 ± 11.9 pmol/min to a nadir of 45.6 ± 10.6 pmol/min (P< .001), a 48% ± 8.4% decline. Plasma glucose and glucagon concentrations did not change significantly either during or after exercise, although there was a matched twofold increase in glucose utilization and disposal rates. We suggest that the reduction in peripheral insulin concentrations during exercise is due to reduced insulin secretion.