Ventricular enlargement in schizophrenia related to volume reduction of the thalamus, striatum, and superior temporal cortex
Ventricular enlargement in schizophrenia related to volume reduction of the thalamus, striatum, and superior temporal cortex
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DOI：
10.1176/appi.ajp.161.1.154
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发表时间：
2004-01-01
影响因子：
17.7
通讯作者：
Buchsbaum, MS
中科院分区：
文献类型：
--
作者：
Gaser, C;Nenadic, I;Buchsbaum, MS
目的：侧脑室增大是精神分裂症患者最常见的宏观脑结构变化之一，尽管其范围和定位各不相同。作者研究了心室增大是否与局部体积损失有关。采用基于变形形态学的全脑形态测量技术分析了39例精神分裂症患者的高分辨率磁共振成像扫描结果。结果：左、右丘脑、后壳核、左颞上回和脑岛体素与脑室脑比呈显著负相关。结论：丘脑萎缩，特别是内侧核和邻近纹状体和岛叶皮质的萎缩，似乎是精神分裂症患者心室增大的重要原因。
Objective: Enlargement of the lateral ventricles is among the most frequently reported macroscopic brain structural changes in schizophrenia, although variable in extent and localization. The authors investigated whether ventricular enlargement is related to regionally specific volume loss.Method. High-resolution magnetic resonance imaging scans from 39 patients with schizophrenia were analyzed with deformation-based morphometry, a voxel-wise whole brain morphometric technique.Results: Significant negative correlations with the ventricle-brain ratio were found for voxels in the left and right thalamus and posterior putamen and in the left superior temporal gyrus and insula.Conclusions: Thalamic shrinkage, especially of medial nuclei and the adjacent striatum and insular cortex, appear to be important contributors to ventricular enlargement in schizophrenia.