Linkage analysis of Alzheimer disease with psychosis
Linkage analysis of Alzheimer disease with psychosis
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DOI：
10.1212/wnl.59.1.118
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发表时间：
2002-07-09
期刊：
影响因子：
9.9
通讯作者：
Sweet, RA
中科院分区：
文献类型：
--
作者：
Bacanu, SA;Devlin, B;Sweet, RA
虽然迟发性AD(LOAD)的部分风险可归因于载脂蛋白E，但对其他基因座的搜索仍在进行中。作者假设，伴有LOAD(LOAD+P)的精神病症状确定了一种潜在的更具病因同质性的AD形式。对LOAD+P家系的连锁分析发现了一个显著的和几个提示性的新连锁信号，这支持了更大的病因同质性的猜测。
Although a portion of risk for late-onset AD (LOAD) is attributable to APOE, the search for other loci is ongoing. The authors hypothesize that psychotic symptoms with LOAD (LOAD+P) identify a potentially more etiologically homogeneous form of AD. Linkage analysis of families with LOAD+P identified one significant and several suggestive novel linkage signals, which bolsters the conjecture of greater etiologic homogeneity.