Cells and the activation of factor VII.
Cells and the activation of factor VII.
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细胞和因子 VII 的激活。
DOI：
10.1159/000217229
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Rapaport,SI
中科院分区：
文献类型：
--
作者：
Rao,LV;Rapaport,SI
因子VII与存在于细胞上或从细胞释放的组织因子（TF）的结合在体内启动TF依赖性凝血。用再脂化TF悬浮液获得的早期数据导致以下假设：所有与组织损伤后暴露的限制性TF位点结合的因子VII可被低浓度的因子Xa、IXa和Vila快速活化为Vila/TF复合物。然而，最新的数据激活因子VII结合TF表达的培养细胞单层支持的假设，并不是所有的VII/TF复合物形成的组织损伤部位容易激活VIIa/TF复合物在止血。这可能与为什么重组因子Vila可以绕过受损的IXa/VIIIa/磷脂复合物止血功能有关。
Binding of factor VII to tissue factor (TF) present on or released from cells initiates TF-dependent coagulation in vivo. Earlier data obtained with relipidated TF suspensions led to the hypothesis that all factor VII bound to limiting TF sites exposed after tissue injury could be rapidly activated to Vila/TF complexes by low concentrations of factor Xa, IXa, and Vila. However, newer data on the activation of factor VII bound to TF expressed on cultured cell monolayers support the hypothesis that not all VII/TF complexes formed at a site of tissue injury are readily activated to VIIa/TF complexes during hemostasis. This is possibly related to why recombinant factor Vila can bypass impaired IXa/VIIIa/phospholipid complex function in hemostasis.