Suppressor T cell action inhibits the expression of an excluded immunoglobulin gene.
Suppressor T cell action inhibits the expression of an excluded immunoglobulin gene.
复制标题
抑制性 T 细胞作用抑制被排除的免疫球蛋白基因的表达。
DOI：
10.1126/science.6222474
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Granner,DK
中科院分区：
文献类型：
--
作者：
Parslow,TG;Milburn,GL;Lynch,RG;Granner,DK
鼠类浆细胞系MOPC-315的细胞合成两种不同的免疫球蛋白轻链：一种是正常的λ II蛋白，它被掺入分泌和表面结合的免疫球蛋白中，另一种是仅在细胞质中发现的截短的无功能λ I蛋白。特发性抑制性T淋巴细胞选择性抑制MOPC-315细胞λ II和λ I特异性信使RNA的表达。这一发现表明，表型排除的轻链基因可以受到免疫调节控制，并表明不同λ同种型的表达可能在免疫球蛋白分泌细胞中协调调节。
Cells of the murine plasmacytoid line MOPC-315 synthesize two distinct immunoglobulin light chains: a normal λIIprotein, which is incorporated into secretory and surface-bound immunoglobulin, and a truncated, nonfunctional λIprotein found only in the cytoplasm. Idiotype-specific suppressor T lymphocytes selectively inhibit the expression of both λII- and λI-specific messenger RNA by MOPC-315 cells. This finding demonstrates that phenotypically excluded light chain genes can be subject to immunoregulatory control and suggests that the expression of divergent λ isotypes may be coordinately regulated in immunoglobulin-secreting cells.