Associations between salivary testosterone levels and cognitive function among 70‐year‐old Japanese elderly: A cross‐sectional analysis of the <scp>SONIC</scp> study
Associations between salivary testosterone levels and cognitive function among 70‐year‐old Japanese elderly: A cross‐sectional analysis of the <scp>SONIC</scp> study
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70 岁日本老年人唾液睾酮水平与认知功能之间的关联：<scp>SONIC</scp> 研究的横断面分析
DOI：
10.1111/ggi.14504
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Gondo Yasuyuki
中科院分区：
文献类型：
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作者：
Hirokawa Kumi;Kasuga Ayaka;Matsumoto Kiyoaki;Omori Yasuko;Masui Yukie;Nakagawa Takeshi;Ogawa Madoka;Ishioka Yoshiko;Inagaki Hiroki;Ikebe Kazunori;Arai Yasumichi;Ishizaki Tatsuro;Kamide Kei;Gondo Yasuyuki
目的：本横断面研究旨在探讨日本70岁无痴呆和卒中老年人唾液睾酮浓度与认知功能之间的关系。方法研究对象为197名69-71岁的日本社区居民。收集他们的唾液样本，并使用日文版蒙特利尔认知评估（MoCA‐J）评估他们的认知功能。参与者还接受了10项回忆和24项识别测试。对179人（106名男性和73名女性）的数据进行了分析，排除了有中风和痴呆病史的人。在调整生活方式因素并分别对男女数据进行分析后，进行多因素logistic回归分析。结果smoca‐J评分显示，睾酮浓度低的男性认知能力低下的风险明显高于睾酮浓度高的男性（校正优势比：4.72,95%置信区间：1.06-21.00），而在女性中没有发现显著的相关性。在第二次试验中，10项回忆测试分数显示，在女性中，较高的睾酮浓度与较高的回忆显著相关（标准化β = 0.24，P= 0.040），而在男性中没有发现显著的关联。老年男性和女性的唾液睾酮浓度与更好的认知能力呈正相关。结论男性和女性的唾液睾酮浓度与认知功能之间存在着不同任务的相关性。Geriatr Gerontol Int 2022；22日:1040 - 1046。
AimThis cross‐sectional study aimed to investigate the associations between salivary testosterone concentrations and cognitive function in 70‐year‐old Japanese elderly people without dementia and stroke.MethodsParticipants were 197 Japanese community‐dwelling people aged 69–71 years. Their salivary samples were collected, and their cognitive function was assessed using the Japanese version of the Montreal Cognitive Assessment (MoCA‐J). Participants were also administered a 10‐item recall and a 24‐item recognition test. The data for 179 (106 men and 73 women) individuals were analyzed, excluding individuals with a past history of stroke and dementia. Multivariate logistic regression analyses were performed after adjusting for lifestyle factors and analyzing data separately for men and women.ResultsMoCA‐J scores showed that men with low testosterone concentrations had a significantly greater risk of low cognitive performance than those with high testosterone concentrations (adjusted odds ratio: 4.72, 95% confidence interval: 1.06–21.00), while no significant association was found in women. The 10‐item recall test scores showed that higher testosterone concentrations were significantly associated with greater recall in the second trial in women (standardized beta = 0.24,P= 0.040), whereas no significant association was found in men. Salivary testosterone concentrations were positively associated with better cognitive performance in older men and women.ConclusionsThe associations between salivary testosterone concentrations and cognitive function were shown by different tasks for men and women.Geriatr Gerontol Int 2022; 22: 1040–1046.