The role of pannexin1 in the induction and resolution of inflammation.
The role of pannexin1 in the induction and resolution of inflammation.
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DOI：
10.1016/j.febslet.2014.03.009
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发表时间：
2014-04-17
期刊：
影响因子：
3.5
通讯作者：
Leitinger N
中科院分区：
文献类型：
--
作者：
Adamson SE;Leitinger N
细胞外ATP是整个炎症级联过程中一个重要的信号分子，它是一个危险信号，导致炎症小体的激活，增强免疫细胞的浸润，以及一些信号级联的微调，包括那些对炎症的解决很重要的信号。最近的研究表明，ATP可以通过pannexin （Panx）通道以受控的方式从细胞中释放出来。Panx1介导的ATP释放参与炎性小体活化和中性粒细胞/巨噬细胞趋化、T细胞活化，Panx1在包括肺、中枢和外周神经系统在内的多种器官中诱导和传播炎症的作用已被证实。对死亡细胞和炎症病灶碎片的识别和清除对炎症的解决至关重要，panx1介导的死亡细胞ATP释放已被证明可以招募吞噬细胞。此外，胞外ATP可以被外核苷酸酶分解成ADP、AMP和腺苷，这在炎症的解决中是至关重要的。Panx1， ATP，嘌呤能受体和外核苷酶共同参与炎症反应过程中的重要反馈回路，因此代表了新疗法的有希望的候选者。
Extracellular ATP is an important signaling molecule throughout the inflammatory cascade, serving as a danger signal that causes activation of the inflammasome, enhancement of immune cell infiltration, and fine-tuning of several signaling cascades including those important for the resolution of inflammation. Recent studies demonstrated that ATP can be released from cells in a controlled manner through pannexin (Panx) channels. Panx1-mediated ATP release is involved in inflammasome activation and neutrophil/macrophage chemotaxis, activation of T cells, and a role for Panx1 in inducing and propagating inflammation has been demonstrated in various organs, including lung and the central and peripheral nervous system. The recognition and clearance of dying cells and debris from focal points of inflammation is critical in the resolution of inflammation, and Panx1-mediated ATP release from dying cells has been shown to recruit phagocytes. Moreover, extracellular ATP can be broken down by ectonucleotidases into ADP, AMP, and adenosine, which is critical in the resolution of inflammation. Together, Panx1, ATP, purinergic receptors, and ectonucleotidases contribute to important feedback loops during the inflammatory response, and thus represent promising candidates for new therapies.
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影响因子：
3.3
作者：
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通讯作者：
Tremblay, Michel J.
影响因子：
20.3
作者：
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通讯作者：
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影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.4049/jimmunol.1000108
发表时间：
2010-08-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
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通讯作者：
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影响因子：
20.1
作者：
Billaud M;Lohman AW;Straub AC;Looft-Wilson R;Johnstone SR;Araj CA;Best AK;Chekeni FB;Ravichandran KS;Penuela S;Laird DW;Isakson BE
通讯作者：
Isakson BE