The Pittsburgh diabetes mellitus study. 3: An increased prevalence with older maternal age.
The Pittsburgh diabetes mellitus study. 3: An increased prevalence with older maternal age.
复制标题
匹兹堡糖尿病研究。
DOI：
10.1007/bf00250892
复制
发表时间：
1983
期刊：
影响因子：
8.2
通讯作者：
Drash,AL
中科院分区：
文献类型：
--
作者：
Wagener,DK;LaPorte,RE;Orchard,TJ;Cavender,D;Kuller,LH;Drash,AL
从匹兹堡儿童医院的连续入院中确定了一系列在17岁之前发病的I型（胰岛素依赖型）糖尿病患者。获得了1006个家族（1085例病例）的家族史资料，其中信息完整。儿童糖尿病的患病率因出生顺序而异，长子的患病率高于预期。年龄超过35岁的母亲所生子女的流行率也有所上升，非常年轻的母亲所生子女的流行率也有所上升。即使在生命表年龄校正后，高龄母亲的后代糖尿病患病率也明显增加。然而，头胎子女流行率的上升和非常年轻母亲子女流行率的上升都可能是由于这一特定人口中这些儿童达到的年龄较大。这表明，母亲的年龄效应是存在的，但出生顺序的影响是缺席时，考虑到年龄。
A series of patients having onset of Type I (insulin-dependent) diabetes mellitus before age 17 years was identified from consecutive admissions to the Children's Hospital of Pittsburgh. Family history data were obtained yielding 1006 families (1085 cases) with complete information. The prevalence of diabetes among the children differed by birth order, with a greater number than expected among first born. There was also an increased prevalence among children born to mothers older than 35 years, as well as an increased prevalence among children of very young mothers. The increased prevalence of diabetes among offspring of older mothers was apparent even after life table age corrections were made. However, both the increased prevalence among first born children and the increased prevalence among children of very young mothers could be attributed to an older attained age of these children in this particular population. This indicated that the maternal age effect was present but a birth order effect was absent when age was taken into account.