Sudden Cardiac Death and Disorders of the QT Interval: Anesthetic Implications and Focus on Perioperative Management.
Sudden Cardiac Death and Disorders of the QT Interval: Anesthetic Implications and Focus on Perioperative Management.
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DOI：
10.1053/j.jvca.2015.07.026
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发表时间：
2015-12
影响因子：
2.8
通讯作者：
H. Ramakrishna;M. O’Hare;F. Mookadam;J. Gutsche;Ronak M. Shah;J. Augoustides
中科院分区：
文献类型：
--
作者：
H. Ramakrishna;M. O’Hare;F. Mookadam;J. Gutsche;Ronak M. Shah;J. Augoustides
ONG QT 综合征 (LQTS) 和短 QT 综合征钠通道病理生理学和 LQTS/SQTS L(SQTS) 是普通人群中发生的遗传性心脏离子通道病，并且与儿童和成人心源性猝死有充分的关联。心源性猝死通常是由持续性室性心动过速（包括心室颤动）引起的。公布的发病率平均每 10,000 人中有 5 至 10 人死亡。在美国，每年约有 300,000 至 450,000 人死于心源性猝死。离子通道病是一组异质性遗传性多系统疾病，包括 Brugada 综合征、儿茶酚胺能多形性室性心动过速和致心律失常性右室心肌病。这些病症有 3 个共同特征：(1) 心脏结构正常，(2) 遗传基础，以及 (3) 致命性心律失常的倾向。它们在围手术期越来越频繁地被认识到，但缺乏治疗这些复杂心律失常患者的指南。本综述讨论了与 LQTS 和 SQTS 相关的围手术期问题，重点是循证管理。
ONG QT SYNDROME (LQTS) and short QT syndrome SODIUM CHANNEL PATHOPHYSIOLOGY AND LQTS/SQTS L(SQTS) are genetic cardiac ion channelopathies that occur in the general population and have a well-documented association with sudden cardiac death both in children and adults. Sudden cardiac death usually is caused by sustained ventricular tachycardia, including ventricular fibrillation. The published incidence averages about 5 to 10 deaths per 10,000 population. In the United States, sudden cardiac death is responsible for about 300,000 to 450,000 deaths per year. The ion channelopathies are a heterogenous group of inherited multisystem disorders that include Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, and arrhythmogenic right ventricular cardiomyopathy. These conditions have 3 features in common: (1) a structurally normal heart, (2) genetic basis, and (3) predisposition to lethal arrhythmias. They are being recognized with increased frequency in the perioperative period, and guidelines for the management of patients with these complex arrhythmias are lacking. This review addresses the perioperative issues associated with LQTS and SQTS, with a focus on evidence-based management.