Molecular and pharmacological properties of insect biogenic amine receptors:: Lessons from Drosophila melanogaster and Apis mellifera
Molecular and pharmacological properties of insect biogenic amine receptors:: Lessons from Drosophila melanogaster and Apis mellifera
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DOI：
10.1002/arch.1055
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发表时间：
2001-09-01
影响因子：
2.2
通讯作者：
Baumann, A
中科院分区：
文献类型：
--
作者：
Blenau, W;Baumann, A
在脊椎动物和无脊椎动物的中枢神经系统中，生物胺是重要的神经活性分子。在生理上，它们可以作为神经递质、神经调质或神经激素。生物胺控制和调节各种生命功能，包括昼夜节律，内分泌，心血管控制，情绪以及学习和记忆。在昆虫中，多巴胺、酪胺、章鱼胺、血清素和组胺等胺通过与主要属于G蛋白偶联受体超家族的特定膜蛋白结合来发挥作用。特别是在果蝇和意大利蜜蜂中，在过去的几年里，对这些受体及其细胞内信号系统的功能作用的理解已经取得了相当大的进展。本文综述了果蝇和蜜蜂生物胺受体的生物化学、分子生物学和药理学特性。昆虫生物化学生理学48：13- 38，2001。(C)2001 Wiley-Liss，Inc.
In the central nervous system (CNS) of both vertebrates and invertebrates, biogenic amines are important neuroactive molecules. Physiologically, they can act as neurotransmitters, neuromodulators, or neurohormones. Biogenic amines control and regulate various vital functions including circadian rhythms, endocrine secretion, cardiovascular control, emotions, as well as learning and memory. In insects, amines like dopamine, tyramine, octopamine, serotonin, and histamine exert their effects by binding to specific membrane proteins that primarily belong to the superfamily of G protein-coupled receptors. Especially in Drosophila melanogaster and Apis mellifera considerable progress has been achieved during the last few years towards the understanding of the functional role of these receptors and their intracellular signaling systems. In this review, the present knowledge on the biochemical, molecular, and pharmacological properties of biogenic amine receptors from Drosophila and Apis will be summarized. Arch. Insect Biochem. Physiol. 48:13-38,2001. (C) 2001 Wiley-Liss, Inc.