Intertribal gene flow between the Ye'cuana and Yanomama: genetic analysis of an admixed village.
Intertribal gene flow between the Ye'cuana and Yanomama: genetic analysis of an admixed village.
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Yecuana 和 Yanomama 之间的部落间基因流动：混合村庄的遗传分析。
DOI：
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发表时间：
1983
影响因子：
2.8
通讯作者：
P. Smouse
中科院分区：
文献类型：
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作者：
J. Long;P. Smouse
与邻近的 Ye'cuana 印第安人村庄的基因交换将两个等位基因 Dia 和 ACPa 引入了 Borabuk 的 Yanomama 印第安村。经过几代后，这些等位基因的频率分别达到了 0.08 和 0.10。这些频率令人费解，因为 Borabuk 的频率高于它们的发源地 Ye'cuana 村。从这些性状中的任何一个获得的祖先比例的单一等位基因估计在生物学上都是不现实的，并且表明混合并不能很好地解释博拉布克的遗传变异。尽管如此，多等位基因混合模型被认为可以对祖先比例进行可靠的估计，并解释 Borabuk 中大量等位基因频率的变化。当将这些结果与正式谱系分析得出的预期进行比较时，可以看到良好的一致性。将从 11 个基因座的等位基因获得的祖先比例的单等位基因估计值与从相同的 11 个基因座获得的多等位基因估计值以及谱系衍生的估计值进行比较，证明了多等位基因方法的优越性。
Genetic exchange with a neighboring village of Ye'cuana Indians had introduced two alleles, Dia and ACPa, into the Yanomama Indian Village of Borabuk. After several generations, these alleles had reached frequencies of 0.08 and 0.10, respectively. These frequencies are puzzling because they are higher in Borabuk than in the Ye'cuana village from which they were derived. Single allele estimates of ancestral proportions obtained from either of these traits are biologically unrealistic and suggest that admixture is not a good explanation for genetic variation in Borabuk. Nevertheless, multiallelic admixture models are seen to produce credible estimates of ancestral proportions and to explain a large amount of allele frequency variation in Borabuk. When these results are compared with expectations derived froma formal pedigree analysis, good agreement is seen. Comparison of single allele estimates of ancestral proportions obtained from alleles at 11 loci, with multiallelic estimates obtained from the same 11 loci and with the pedigree-derived estimates, demonstrates the superiority of the multiallelic approach.