A distributed neural network model for the distinct roles of medial and lateral HVC in zebra finch song production
A distributed neural network model for the distinct roles of medial and lateral HVC in zebra finch song production
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DOI：
10.1152/jn.00917.2016
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发表时间：
2017-08-01
影响因子：
2.5
通讯作者：
Bertram, Richard
中科院分区：
文献类型：
--
作者：
Galvis, Daniel;Wu, Wei;Bertram, Richard
雄性斑胸草雀发出一种由标准音节序列组成的歌曲，从导师那里学到，并在整个成年生活中重复。负责这种行为的大部分神经回路位于皮质运动前区HVC（首字母缩略词是名称）。在我们实验室最近的一项研究中，我们发现HVC内侧部分的部分双侧消融对歌曲的影响与外侧部分的双侧消融有质的不同。在这份报告中，我们描述了一个可以解释这些数据的神经网络组织，并在这样做的过程中暗示了其他大脑核团在歌曲产生中的关键作用。我们还建议，音节和它们之间的差距分别编码的神经链内HVC，和音节和间隙的定时机制是不同的。该模型的设计原则为内侧和外侧HVC电路分配了不同的角色，解释了内侧和外侧消融的数据。此外，尽管在我们的模型中，歌曲序列的神经编码分布在几个脑核中，但它解释了数据显示HVC的冷却均匀地拉伸音节，并且比间隙更大程度地拉伸音节。最后，该模型对内侧和外侧HVC消融的影响细节进行了意料之外的预测，然后通过对这些先前获得的行为数据进行重新分析来证实。新&值得注意的是，斑胸草雀的歌声由一串以几乎不变的序列重复的音节组成。我们提出了一个神经网络组织，可以解释最近的数据表明，内侧和外侧部分的运动前皮质核HVC有不同的作用，斑胸草雀的歌曲生产。我们的模型解释了这些数据，以及冷却HVC对歌曲影响的数据，并做出了我们在唱歌的鸟中测试的预测。
Male zebra finches produce a song consisting of a canonical sequence of syllables, learned from a tutor and repeated throughout its adult life. Much of the neural circuitry responsible for this behavior is located in the cortical premotor region HVC (acronym is name). In a recent study from our laboratory, we found that partial bilateral ablation of the medial portion of HVC has effects on the song that are qualitatively different from those of bilateral ablation of the lateral portion. In this report we describe a neural network organization that can explain these data, and in so doing suggests key roles for other brain nuclei in the production of song. We also suggest that syllables and the gaps between them are each coded separately by neural chains within HVC, and that the timing mechanisms for syllables and gaps are distinct. The design principles underlying this model assign distinct roles for medial and lateral HVC circuitry that explain the data on medial and lateral ablations. In addition, despite the fact that the neural coding of song sequence is distributed among several brain nuclei in our model, it accounts for data showing that cooling of HVC stretches syllables uniformly and to a greater extent than gaps. Finally, the model made unanticipated predictions about details of the effects of medial and lateral HVC ablations that were then confirmed by reanalysis of these previously acquired behavioral data.NEW & NOTEWORTHY Zebra finch song consists of a string of syllables repeated in a nearly invariant sequence. We propose a neural network organization that can explain recent data indicating that the medial and lateral portions of the premotor cortical nucleus HVC have different roles in zebra finch song production. Our model explains these data, as well as data on the effects on song of cooling HVC, and makes predictions that we test in the singing bird.