Role of viscoelasticity in the tube model of airway reopening .2. Non-Newtonian gels and airway simulation
Role of viscoelasticity in the tube model of airway reopening .2. Non-Newtonian gels and airway simulation
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DOI：
10.1152/jappl.1996.80.5.1649
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发表时间：
1996-05-01
影响因子：
3.3
通讯作者：
Jamieson, AM
中科院分区：
文献类型：
--
作者：
Hsu, SH;Strohl, KP;Jamieson, AM
研究了粘弹性凝胶作为衬里流体对气道管模型中压力-速度关系的影响（Gaver等，J.Appl.Physiol.69：74-85，1990）。流动不稳定性观察到由于在流动条件下的粘弹性的溶胶-凝胶转变的发生。我们进一步报告测量气道分泌物的粘弹性。气道分泌物在小应变下呈凝胶状，屈服应力为4-7 dyn/cm（2）。咽部气道分泌物的弹性比气管分泌物低。气道重新开放的过程中模拟使用的韦伯肺几何形状，通过将本构方程从模型凝胶研究和利用气道分泌物的流变学数据。在这些模拟中，当假设衬里流体的流变学特性与咽分泌物的流变学特性相似时，第8-14代气道中的流动不稳定性会产生“爆裂”现象。在这些研究的基础上，气道分泌物的弹性在气道重新开放中起重要作用。
The influence of viscoelastic gels as lining fluids on the pressure-velocity relationships in an airway tube model (Gaver et al. J. Appl. Physiol. 69: 74-85, 1990) was examined. A flow instability was observed due to the occurrence of a sol-gel transition in the viscoelastic properties under flow conditions. We further report measurements of the viscoelastic properties of airway secretions. Airway secretions are gels under small strains and have a yield stress of 4-7 dyn/cm(2). Secretions from the pharyngeal airway show lower elasticity than secretions from the trachea. The airway reopening process is simulated using a Weibel lung geometry by incorporating the constitutive equations from the model gel studies and utilizing the rheological data on airway secretions. In these simulations, a ''popping-open'' phenomenon arises from a flow instability in airway generations 8-14 when the rheological properties of the lining fluids are assumed to be similar to those of pharyngeal secretions. On the basis of these studies, the elasticity of airway secretions plays an important role in airway reopening.