Clinicopathological outline of dementia with Lewy bodies applying the revised criteria: The hisayama study
Clinicopathological outline of dementia with Lewy bodies applying the revised criteria: The hisayama study
复制标题
DOI：
10.1111/j.1750-3639.2008.00169.x
复制
发表时间：
2008-07-01
期刊：
影响因子：
6.4
通讯作者：
Iwaki, Toru
中科院分区：
文献类型：
--
作者：
Fujimi, Kouhei;Sasaki, Kensuke;Iwaki, Toru
为了探讨 2005 年修订的路易体痴呆 (DLB) 标准的有效性，我们检查了基于社区的连续尸检病例。 10.3% 的非痴呆受试者和 31.2% 的痴呆受试者表现出路易体病理。将修订后的病理标准应用于205名痴呆受试者中，LB病理类型为脑干型11例（5.4%），边缘型24例（11.7%），弥漫新皮质型24例（11.7%），但也有很多受试者不完全符合标准。无论性别如何，路易体 (LB) 的患病率几乎相同；然而，女性 LB 病理的程度比男性更严重。 DLB 因伴随阿尔茨海默病病理改变的可能性如下：27 例（13.2%）显示低可能性，16 例（7.8%）显示中等可能性，16 例（7.8%）显示高可能性。由于病理性中似然和高似然DLB组的DLB临床特征数量显着高于低似然DLB组或无LB组，因此中似然和高似然DLB组均应被视为病理性DLB。
To explore the validity of the criteria for dementia with Lewy bodies (DLB) revised in 2005, we examined community based consecutive autopsy cases. 10.3% of the non-demented subjects and 31.2% of the demented subjects showed the Lewy body pathology. Applying the revised pathological criteria to the 205 demented subjects, the types of LB pathology of 11 cases (5.4%) were brainstem-predominant, 24 cases (11.7%) were limbic type and 24 cases (11.7%) were diffuse neocortical type, although there were many subjects not to fit the criteria exactly. The prevalence of Lewy bodies (LBs) was almost same regardless of gender; however, the extent of the LB pathology among females was more severe than that in males. The likelihood of DLB being modified by concomitant Alzheimer's pathology was as follows: 27 cases (13.2%) showed low likelihood, 16 cases (7.8%) showed intermediate likelihood and 16 cases (7.8%) showed high likelihood. Since the numbers of clinical features of DLB were significantly higher in the pathological intermediate and high likelihood DLB groups than in the low likelihood DLB group or no LB group, both the intermediate and high likelihood groups of DLB should be considered as pathological DLB.