Relationship of pancreas volume to tobacco smoking and alcohol consumption following pancreatitis
Relationship of pancreas volume to tobacco smoking and alcohol consumption following pancreatitis
复制标题
DOI：
10.1016/j.pan.2019.10.009
复制
发表时间：
2020-01-01
期刊：
影响因子：
3.6
通讯作者：
Petrov, Maxim S.
中科院分区：
文献类型：
--
作者：
Stuart, Charlotte E. A.;Singh, Ruma G.;Petrov, Maxim S.
背景：吸烟和饮酒是胰腺疾病的既定危险因素。随着成像方式（如磁共振（MR）成像）的最新进展，出现了研究胰腺大小的机会，在健康和疾病。研究调查吸烟，饮酒和总胰腺体积（TPV）-胰腺外分泌储备的整体措施-之间的关系缺乏。本研究的目的是调查MR衍生的TPV和吸烟/饮酒consumption.Methods之间的关联：本横断面研究招募个人胰腺炎和健康对照的历史。一份经过验证的问卷被用来确定当前和一生的吸烟和饮酒情况。由两名独立评分者使用MR图像对TPV进行量化。广义加性模型和线性回归分析进行人口统计学，代谢和胰腺炎相关factors.Results调整：共107人胰腺炎和38名健康对照。在未校正和校正分析中，胰腺炎后任何吸烟/饮酒类别的个体与健康对照组之间的TPV无统计学显著差异。在胰腺炎患者中，多元线性回归发现TPV与7个吸烟和饮酒相关变量之间无相关性。仅限于首次胰腺炎发作后不戒烟或不饮酒的个体的敏感性分析未得出TPV的统计学显著性。在事后分析中，年龄与TPV在最调整模型中呈显著负相关（p = 0.016）。结论：这是第一个研究吸烟，饮酒和MR衍生的TPV胰腺炎之间的关联。似乎年龄，而不是吸烟或饮酒，与TPV显著降低相关。(C)2019年IAP和EPC。Elsevier B. V.出版，保留所有权利。
Background: Tobacco smoking and alcohol consumption are established risk factors for diseases of the pancreas. With the recent advances in imaging modalities (such as magnetic resonance (MR) imaging), opportunities have arisen to study pancreas size, in both health and disease. Studies investigating the relationship between tobacco smoking, alcohol consumption, and total pancreas volume (TPV) - a holistic measure of pancreatic exocrine reserve - are lacking. The aim of the present study was to investigate the associations between MR-derived TPV and tobacco smoking/alcohol consumption.Methods: This cross-sectional study recruited individuals with a history of pancreatitis and healthy controls. A validated questionnaire was used to ascertain current and lifetime tobacco smoking and alcohol consumption. TPV was quantified using MR images by two independent raters. Generalized additive models and linear regression analyses were conducted and adjusted for demographic, metabolic, and pancreatitis-related factors.Results: A total of 107 individuals following pancreatitis and 38 healthy controls were included. There was no statistically significant difference in TPV between any of the tobacco smoking/alcohol consumption categories of individuals following pancreatitis and healthy controls, in both unadjusted and adjusted analyses. In individuals following pancreatitis, multivariate linear regression found no association between TPV and 7 smoking- and alcohol-related variables. Sensitivity analyses constrained to individuals who did not abstain from either smoking or drinking following their first attack of pancreatitis did not yield statistical significance with TPV. In post-hoc analysis, age was significantly inversely associated with TPV in the most adjusted model (p = 0.016).Conclusions: This is the first study to investigate the association between tobacco smoking, alcohol consumption, and MR-derived TPV following pancreatitis. It appears that age, but not tobacco smoking or alcohol consumption, is associated with a significantly reduced TPV. (C) 2019 IAP and EPC. Published by Elsevier B.V. All rights reserved.