Current trends in the anti-photoaging activities and mechanisms of dietary non-starch polysaccharides from natural resources
Current trends in the anti-photoaging activities and mechanisms of dietary non-starch polysaccharides from natural resources
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DOI：
10.1080/10408398.2021.1939263
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发表时间：
2021-06
影响因子：
10.2
通讯作者：
Wanzi Yao;Xiaoyong Chen;Xiong Li;Shiyuan Chang;Mouming Zhao;Lijun You
中科院分区：
文献类型：
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作者：
Wanzi Yao;Xiaoyong Chen;Xiong Li;Shiyuan Chang;Mouming Zhao;Lijun You
摘要光老化是一个复杂的多阶段过程，主要由暴露在阳光下的紫外线（UV）辐射引发。光老化诱导DNA损伤和氧化应激，引发炎症反应和基质金属蛋白酶（MMPs）表达增加，这导致皮肤外观、结构和功能的累积变化，并最终导致皮肤癌变。来源于生物资源的膳食多糖具有良好的生物活性，已被广泛应用于保健食品、化妆品、药品等领域。然而，系统介绍其抗光老化的作用和机制是有限的。本文从氧化应激、DNA损伤、基质金属蛋白酶调节、炎症反应、黑素生成等方面综述了近年来天然食用非淀粉多糖抗紫外光老化的研究进展，重点介绍了其抗紫外光老化的细胞和分子机制。本文的研究有助于了解天然非淀粉多糖的抗光老化功能，并进一步在药物和功能食品中的应用。
Abstract Photoaging is a complex and multistage process triggered mainly by ultraviolet (UV) radiation due to exposure to sunlight. Photoaging induces DNA damage and oxidative stress that initiate an inflammatory response and an increase of matrix metalloproteinases (MMPs) expression, which results in cumulative changes in skin appearance, structure, and functions, and eventually causes skin carcinogenesis. Dietary polysaccharides from bio-resources have been utilized as functional ingredients in healthy food, cosmetics, and drug due to their good bioactivities. However, a systematic introduction to their effects and underlying mechanisms in anti-photoaging is limited. This review discusses the damage and pathogenesis of UV-induced photoaging and summarizes the up-to-date advances in research on the anti-photoaging activity of non-starch polysaccharides from natural edible resources considering the influence of oxidative stress, DNA damage, MMPs regulation, inflammation, and melanogenesis, primarily focusing on the cellular and molecular mechanisms. This paper will help to understand the anti-photoaging functions of dietary non-starch polysaccharides from natural resources and further application in drug and functional food.