Cytotoxicity and photocytotoxicity of structure-defined water-soluble C60/micelle supramolecular nanoparticles
Cytotoxicity and photocytotoxicity of structure-defined water-soluble C60/micelle supramolecular nanoparticles
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DOI：
10.1088/0957-4484/22/23/235604
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发表时间：
2011-06-10
期刊：
影响因子：
3.5
通讯作者：
Wang, Xiaosong
中科院分区：
文献类型：
--
作者：
Metanawin, Tanapak;Tang, Tian;Wang, Xiaosong
通过PS-b-PDMA嵌段共聚物胶束和C-60的自组装，制备了具有不同含量的C-60位于胶束核表面的定义明确的水溶性C-60/胶束分级胶体。在红光照射下，复合材料可以产生大量的活性氧。细胞研究表明，胶体是强烈相关的，或内化，细胞孵育2小时后，但在黑暗中没有表现出明显的毒性。相反，当胶体孵育的细胞暴露于红光时，观察到有效的细胞杀伤。这表明，超分子胶体作为光敏剂用于光动力治疗癌症是有前途的。
Well-defined, water-soluble C-60/micelle hierarchical colloids with varied amounts of C-60 sitting on the surface of micellar cores were prepared via the self-assembly of PS-b-PDMA block copolymer micelles and C-60. The composites can generate a significant amount of reactive oxygen upon irradiation with red light. Cell studies showed that the colloids were either strongly associated with, or internalized by, the cells after 2 h incubation, but did not show obvious toxicity in the dark. In contrast, efficient cell killing was observed when the colloid-incubated cells were exposed to red light. This indicates that the supramolecular colloids are promising as photosensitizers for photodynamic cancer therapy.