Effect of aripiprazole augmentation for the depressive symptoms changes with progression of Lewy body disease.
Effect of aripiprazole augmentation for the depressive symptoms changes with progression of Lewy body disease.
复制标题
阿立哌唑增强治疗抑郁症状的效果随着路易体病的进展而变化。
DOI：
10.1111/pcn.12479
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Ozaki N.
中科院分区：
文献类型：
--
作者：
Iwamoto K;Fujishiro H;Ozaki N.
尽管晚年抑郁症是主要问题，但一半患者对一线药物治疗没有反应。需要采取辅助策略，最近的研究表明阿立哌唑增强治疗是有效的治疗方法。该报告表明，阿立哌唑增强治疗可以掩盖晚年抑郁症中的路易体病。阿立哌唑增强治疗最初可改善路易体病的抑郁症状，但不会引发锥体外系功能障碍，随着疾病的进展，最终效果会降低并引起锥体外系功能障碍。路易体病的进展可能会影响阿立哌唑增强治疗的疗效和耐受性。临床医生应重新考虑对阿立哌唑增强治疗有反应的晚年抑郁患者的诊断。
Although late-life depression is major concern, half of patients fail to respond to first-line pharmacotherapy. Secondary strategies are required and recent study showed that aripiprazole augmentation is useful treatment. This report shows that aripiprazole augmentation can obscure Lewy body disease in late-life depression. Aripiprazole augmentation initially ameliorates depressive symptoms of Lewy body disease without triggering extrapyramidal dysfunction and eventually becomes less effective and evokes extrapyramidal dysfunction as the disease progresses. Progression of Lewy body disease may affect both efficacy and tolerability of aripiprazole augmentation. Clinician should reconsider diagnosis of depressive patients in late-life who are responsive to aripiprazole augmentation.