Interleukin-6 blood level is associated with circulating carcinoembryonic antigen and prognosis in patients with colorectal cancer
Interleukin-6 blood level is associated with circulating carcinoembryonic antigen and prognosis in patients with colorectal cancer
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DOI：
10.1007/s10434-000-0133-7
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发表时间：
2000-03-01
影响因子：
3.7
通讯作者：
Jessup, JM
中科院分区：
文献类型：
--
作者：
Belluco, C;Nitti, D;Jessup, JM
背景：白细胞介素-6（IL-6）是一种重要的促炎细胞因子，具有刺激炎症和细胞生长的多重作用。实验数据表明，癌胚抗原（CEA）诱导IL-6的全身生产和IL-6可以刺激肿瘤细胞在转移部位的生长。我们检验了血液中IL-6浓度与循环CEA量和结直肠癌患者预后相关的假设。方法：采用酶免疫法测定208例I期至IV期结直肠癌患者术前血清中CEA和IL-6浓度。线性回归分析显示CEA和IL-6血清值之间存在显著相关性（r = 0.544; R-2 = 0.296; P <0.001）。III期和IV期疾病患者的IL-6血清浓度显著高于I期和II期疾病患者。在I期至III期患者中，IL-6浓度为10 pg/ml或更低的病例（n = 94）的5年生存率为83%，IL-6浓度大于10 pg/ml的病例为56%（n = 54; P = 0.001;中位随访时间为46个月）。通过多因素分析，IL-6浓度大于10 pg/ml是生存的独立预后因素（相对危险度= 1.820; P = 0.020）。结论：在结直肠癌患者中，血中IL-6浓度与高循环CEA和晚期相关。此外，IL-6浓度超过10 pg/ml是生存的独立阴性预后标志物。
Background: Interleukin-6 (IL-6) is an important proinflammatory cytokine that has multiple effects on stimulating inflammation and cell growth. Experimental data suggest that carcinoembryonic antigen (CEA) induces the systemic production of IL-6 and that IL-6 may stimulate tumor cell growth at metastatic sites. We tested the hypothesis that blood concentrations of IL-6 are associated with the amount of circulating CEA and with prognosis in patients with colorectal cancer.Methods: CEA and IL-6 concentrations were measured by using enzyme immunoassay in preoperative serum samples from 208 patients with stages I through IV colorectal cancer.Results: Linear regression analysis showed a significant association between serum values of CEA and IL-6 (r = .544; R-2 = .296; P < .001). Patients with stage III and stage IV disease had a significantly higher IL-6 serum concentration than those with stage I and stage II disease. In patients with stages I through III, 5-year survival was 83% in cases with concentrations of IL-6 at 10 pg/ml or less (n = 94) and 56% in cases with IL-6 concentrations of more than 10 pg/ml (n = 54; P = .001; median follow-up time, 46 months). By using multivariate analysis, an IL-6 concentration of more than 10 pg/ml was an independent prognostic factor of survival (relative risk = 1.820; P = .020).Conclusions: In patients with colorectal cancer, blood concentration of IL-6 is associated with high circulating CEA and advanced stage. Furthermore, an IL-6 concentration of more than 10 pg/ml is an independent negative prognostic marker of survival.