Multimodal polarization system for imaging skin cancer
Multimodal polarization system for imaging skin cancer
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DOI：
10.1134/s0030400x0912008x
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发表时间：
2009-12-01
影响因子：
0.6
通讯作者：
Yaroslavskaya, A. N.
中科院分区：
文献类型：
--
作者：
Salomatina-Motts, E.;Neel, V. A.;Yaroslavskaya, A. N.
创建了一种光学系统，该光学系统能够借助于由组织弹性散射的光的光谱分辨偏振成像和外源荧光团的荧光偏振成像来真实的实时地检测体内肿瘤形成。系统的性能特性，如分辨率，视场，和辐射的功率密度和稳定性，以及校准G因子，被确定。在临床条件下测试系统的功能。弹性散射和荧光偏振图像的光谱分辨信号从体内的伤口表面和从活检材料检测。通过与组织学研究结果的比较，证明了该方法的可靠性。
An optical system is created that is capable of detecting tumor formations in vivo in real time by means of the spectrally resolved polarization imaging of light elastically scattered by tissue and imaging of fluorescence polarization of exogenous fluorophores. The performance characteristics of the system, such as the resolution, field of view, and power density and stability of the radiation, as well as the calibration G factor, are determined. The functionality of the system is tested under clinical conditions. Spectrally resolved signals of elastic scattering and fluorescence polarization images are detected both from the wound surface in vivo and from the bioptic material. The reliability of the method is proven by comparing the results with the data of histological studies.