Cicatricial organising pneumonia associated with fibrosing interstitial pneumonia- a clinicopathological study
Cicatricial organising pneumonia associated with fibrosing interstitial pneumonia- a clinicopathological study
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与纤维化间质性肺炎相关的瘢痕机化性肺炎——临床病理学研究
DOI：
10.1111/his.14427
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发表时间：
2021
期刊：
影响因子：
6.4
通讯作者：
Fukuoka Junya
中科院分区：
文献类型：
--
作者：
Zaizen Yoshiaki;Tabata Kazuhiro;Yamano Yasuhiko;Takei Reoto;Kataoka Kensuke;Shiraki Akira;Nishimura Koichi;Furuyama Kazuto;Bychkov Andrey;Hoshino Tomoaki;Johkoh Takeshi;Kondoh Yasuhiro;Fukuoka Junya
目的：最近对瘢痕性机化性肺炎（ciOP）的认识表明，ciOP可能类似或模拟纤维化间质性肺炎;然而，关于受影响的人群、发病机制、临床相关性和特征存在很大的不确定性。在这项研究中，我们比较了纤维化间质性肺炎的特点与不ciOP.Methods和resultsWe招募了121例患者的咨询档案，其病理结果是纤维化间质性肺炎，并为他们提供了后续的临床数据。我们回顾了这些病例的组织病理学，并根据是否显示ciOP对其进行分类。比较两组患者的临床病理特征。48例患者（39.7%）发现了CiOP，其组织病理学特征是肺泡腔内致密胶原纤维沉积，但不破坏肺结构。在12个月随访期间，没有ciOP病例发生急性加重。与ciOP组有更严重的扩散障碍，但这一点，连同限制性呼吸障碍，改善显着相比，没有ciOP.ConclusionCiOP组是一种常见的纤维化间质性肺炎的组织病理学发现。与急性加重或肺功能降低无关。
AimsThe recent recognition of cicatricial organising pneumonia (ciOP) indicates that the ciOP may resemble or simulate fibrotic interstitial pneumonia; however, there has been great uncertainty regarding the affected populations, pathogenesis, clinical relevance and characteristics. In this study, we compared the characteristics of fibrotic interstitial pneumonia with and without ciOP.Methods and resultsWe enrolled 121 patients from the consultation archive whose pathological findings were fibrotic interstitial pneumonia and for whom follow‐up clinical data were available. We reviewed these cases histopathologically and classified them according to whether or not they showed ciOP. We compared the clinicopathological features between the two groups. CiOP, histopathologically characterised by deposition of dense collagenous fibres within the alveolar space without destruction of the lung structure, was found in 48 patients (39.7%). None of the cases with ciOP experienced acute exacerbation during 12 months’ follow‐up. The group with ciOP had more severe diffusion impairment but this, together with restrictive ventilatory impairment, improved significantly compared to the group without ciOP.ConclusionCiOP is a histopathological finding commonly found in fibrotic interstitial pneumonia. It does not relate to acute exacerbation or decrease in pulmonary function.