Adiponectin represents an independent cardiovascular risk factor predicting serum HDL‐cholesterol levels in type 2 diabetes
Adiponectin represents an independent cardiovascular risk factor predicting serum HDL‐cholesterol levels in type 2 diabetes
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DOI：
10.1016/s0014-5793(03)00568-4
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发表时间：
2003-06
期刊：
影响因子：
3.5
通讯作者：
B. Zietz;H. Herfarth;G. Paul;A. Ehling;U. Müller-Ladner;J. Schölmerich;A. Schäffler
中科院分区：
文献类型：
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作者：
B. Zietz;H. Herfarth;G. Paul;A. Ehling;U. Müller-Ladner;J. Schölmerich;A. Schäffler
低水平的高密度脂蛋白（HDL）-胆固醇代表了一个独立的心血管风险因素，除了减少体力活动外，导致HDL-胆固醇水平降低的机制尚不清楚。我们的目的是检验这一假设，即脂联素提供了2型糖尿病和低水平HDL-胆固醇之间缺失的联系，独立于常见的代谢危险因素。对523例2型糖尿病患者血清脂联素水平及脂代谢指标进行了检测。即使校正年龄、性别、BMI和空腹胰岛素浓度后，血清脂联素水平与2型糖尿病患者的HDL-胆固醇水平高度显著（P<0.0001）且呈正相关（回归分析：r=0.86）。结论：脂联素似乎可以预测2型糖尿病患者的HDL-胆固醇水平。低水平的脂联素与低水平的HDL-胆固醇相关，独立于常见的代谢风险因素，因此代表2型糖尿病的独立心血管风险因素。因此，脂联素是治疗血脂异常的一个潜在的新药物靶点。
Low levels of high‐density lipoprotein (HDL)‐cholesterol represent an independent cardiovascular risk factor and, besides reduced physical activity, mechanisms leading to decreased HDL‐cholesterol levels are not known. We aimed to test the hypothesis, that adiponectin provides a missing link between type 2 diabetes and low levels of HDL‐cholesterol, independent from common metabolic risk factors. 523 patients with type 2 diabetes were investigated for adiponectin serum levels and parameters of lipid metabolism. Even after correction for age, gender, BMI and fasting insulin concentration, serum levels of adiponectin were highly significant (P<0.0001) and positively (regression analysis:r=0.86) associated with HDL‐cholesterol levels in type 2 diabetes. Conclusion: adiponectin seems to predict HDL‐cholesterol levels in patients with diabetes mellitus type 2. Low levels of adiponectin are associated with low levels of HDL‐cholesterol independently from common metabolic risk factors and therefore represent an independent cardiovascular risk factor in type 2 diabetes. Thus, adiponectin is a potentially new drug target in the treatment of dyslipidaemia.