Diffusion-weighted MR imaging of the hippocampus and temporal white matter in Alzheimer's disease
Diffusion-weighted MR imaging of the hippocampus and temporal white matter in Alzheimer's disease
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DOI：
10.1016/s0022-510x(98)00043-4
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发表时间：
1998-04-01
影响因子：
4.4
通讯作者：
Abe, K
中科院分区：
文献类型：
--
作者：
Hanyu, H;Sakurai, H;Abe, K
我们使用冠状扩散加权磁共振（MR）成像研究了8名可能患有阿尔茨海默病（AD）的患者、10名可能患有AD的患者和10名年龄匹配的对照组的海马和颞白质（颞干）中水扩散的变化。推导了三个正交轴的表观扩散系数（ADC），并计算了扩散各向异性指数(IDA=ADC（max-min)/ADC(mean)）。虽然对照组和患者海马体的ADC和IDA值没有显著差异，但AD患者颞干的垂直（上-下）ADC值和ADC（平均值）值明显高于对照组，因此可能或可能患有AD的患者的IDA值明显低于对照组。此外，颞干IDA值与临床严重程度显著相关。这些结果表明，纤维密度降低，如轴突膜或髓鞘的破坏和损失，发生在颞干早期，可能是由于包括内侧颞叶在内的灰质病理相关的继发性变性。(C) 1998爱思唯尔科学有限公司
We investigated the changes in water diffusion in the hippocampus and the temporal white matter (the temporal stem) in eight patients with possible Alzheimer's disease (AD), 10 patients with probable AD, and 10 age-matched controls, using coronal diffusion-weighted magnetic resonance (MR) imaging. Apparent diffusion coefficients (ADCs) were derived for the three orthogonal axes and an index of diffusion anisotropy (IDA=ADC(max-min)/ADC(mean)) was then calculated. Although no significant differences were found in ADC and IDA values in the hippocampal body between controls and patients, vertical (superior-inferior) ADC values and ADC(mean) values in the temporal stem of patients with AD were significantly higher than those in controls, and IDA values were therefore significantly lower in patients with possible or probable AD than those in controls. Moreover, IDA values in the temporal stem were significantly correlated with the clinical severity. These results suggest that decreased fiber density, such as the disruption and loss of axonal membranes or myelin, occur early in the temporal stem, probably due to secondary degeneration related to grey matter pathology including the medial temporal lobe. (C) 1998 Elsevier Science B.V.