Relationship of Body Fat Distribution Pattern to Atherogenic Risk Factors in NIDDM: Preliminary Results
Relationship of Body Fat Distribution Pattern to Atherogenic Risk Factors in NIDDM: Preliminary Results
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NIDDM 中体脂肪分布模式与致动脉粥样硬化危险因素的关系：初步结果
DOI：
10.2337/diacare.11.2.103
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发表时间：
1988
期刊：
影响因子：
16.2
通讯作者：
I. Leeuw
中科院分区：
文献类型：
--
作者：
L. Gaal;E. Rillaerts;W. Creten;I. Leeuw
由于最近的知识表明，男性脂肪沉积的分布可能是一个更好的预测心血管疾病比单纯的肥胖程度，动脉粥样硬化的一些危险因素进行了评估，在51名中年男性非胰岛素依赖型糖尿病。腹部肥胖（腰/臀比，WHR）与代谢控制参数，血脂参数和已知的血管并发症在三个不同的组。在腹部肥胖组中，平均年血红蛋白A1显著（P <0.01）高于无腹部脂肪分布的患者。WHR最高组的动脉粥样硬化指数显著增加，而高密度脂蛋白胆固醇（HDL-chol）水平在上半身脂肪分布的两组中均显著降低。外周血管疾病、冠状动脉缺血性心脏病和高血压的发生率在腹部脂肪分布的糖尿病受试者中最为突出。WHR与HDL-chol之间以及WHR与总胆固醇/ HDL-chol比率之间存在高度显着（P < .001）相关性;在校正体重指数后，这种显着相关性仍然存在。腰臀比与收缩压和舒张压之间也存在类似的相关性。这些结果表明，腹部脂肪过多，即使没有明显的肥胖，与更差的糖尿病代谢控制，心血管并发症和血脂水平的关联，实际上被认为在动脉粥样硬化形成中发挥重要作用。
Because recent knowledge indicates that the distribution of fat deposits in men may be a better predictor of cardiovascular disease than the degree of obesity alone, some risk factors for atherosclerosis were evaluated in 51 middle-aged men with non-insulin-dependent diabetes mellitus. Abdominal adiposity (waist/hip ratio, WHR) was related to parameters of metabolic control, lipid parameters, and known vascular complications in three different groups. In groups with abdominal obesity, mean annual hemoglobin A1 was significantly (P < .01) higher than in patients without an abdominal fat distribution. Atherogenic index was significantly increased in the group with the highest WHR and highdensity lipoprotein cholesterol (HDL-chol) levels were significantly decreased in both groups with upper-body fat distribution. The frequency of peripheral vascular disease, coronary ischemic heart disease, and hypertension was most prominent in diabetic subjects with an abdominal fat mass distribution. A highly significant (P < .001) correlation was present between WHR and HDL-chol and WHR and the total-cholesterol/ HDL-chol ratio; this significant correlation remains after correction for body mass index. A similar correlation could be found between WHR and systolic and diastolic blood pressures. These results demonstrate an association of excess abdominal fat, even without manifest obesity, with worse diabetes metabolic control, cardiovascular complications, and blood lipid levels actually considered to play an important role in atherogenesis.
影响因子：
9.8
作者：
EVANS, DJ;HOFFMANN, RG;KISSEBAH, AH
通讯作者：
KISSEBAH, AH